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生物来源
mouse
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
VPS4-110, monoclonal
表单
buffered aqueous solution
分子量
antigen ~50 kDa
种属反应性
mouse, canine, bovine, human, rat
浓度
~1.0 mg/mL
技术
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using whole extracts of mouse 3T3 or human HEK-293 cells.
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... VPS4A(27183)
mouse ... Vps4a(116733)
rat ... Vps4a(246772)
一般描述
Monoclonal Anti-VPS4A (mouse IgG1 isotype) is derived from the hybridoma VPS4-110 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human VPS4A, conjugated to KLH.
Vacuolar-protein-sorting factor 4A (VPS4A) is an AAAtype ATPase, encoded by the gene mapped to human chromosome 16q22.1. The encoded protein is a member of vacuolar sorting protein family. The protein is characterized by a canonical AAA ATPase cassette followed by an N-terminal MIT (microtubule interacting and trafficking) domain.
应用
Monoclonal Anti-VPS4A antibody has been used in
- immunoblotting
- immunoprecipitation
- immunolabelling
生化/生理作用
Vacuolar-protein-sorting factor 4A (VPS4A) plays a vital role in lysosomal/endosomal membrane trafficking. It is also involved in the regulation of exosome biogenesis. Downregulated expression of the gene leads to the development of hepatocellular carcinoma (HCC). Thus, VPS4 is considered to be an effective tumor suppressor for HCC. Mutation of the gene leads to defective multivesicular body formation.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
A fourth locus for autosomal dominant hypercholesterolemia maps at 16q22.1
Marques-Pinheiro A
European Journal of Human Genetics, 18, 1236-1242 (2010)
Disruption of Neurexin 1 Associated with Autism Spectrum Disorder
Kim HG
American Journal of Human Genetics, 82, 199-207 (2008)
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A
Scott A
Proceedings of the National Academy of Sciences of the USA, 102, 13813-13818 (2005)
Comparative sequence and expression analyses of four mammalian VPS4 genes
Beyer A
Gene, 305, 47-59 (2003)
Triggered recruitment of ESCRT machinery promotes endolysosomal repair
Skowyra M L, et al.
Science, 360(6384), eaar5078-eaar5078 (2018)
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