推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~100 kDa
种属反应性
human
包装
antibody small pack of 25 μL
浓度
~1.5 mg/mL
技术
immunoprecipitation (IP): 15-30 μg using HEK-293T cells over expressing human cPLA2
western blot: 1.5-3 μg/mL using extracts of HEK-293T cells over expressing human cPLA2
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PLA2G4A(5321)
一般描述
Download the CofA, SDS and IFU specific to your product lot and format
Fragment mixture prepared by cleavage of λDNA with Hind III.
The product is also available as DNA Molecular Weight Marker II, Digoxigenin-labeled.
Size Range: 0.12 to 23.1 kbp
Contents
Ready-to-use solution, 250 μg/mL, in TE buffer (Tris-HCl, 1 mM EDTA, pH 8.0)
Fragment mixture prepared by cleavage of λDNA with Hind III.
The product is also available as DNA Molecular Weight Marker II, Digoxigenin-labeled.
Size Range: 0.12 to 23.1 kbp
Contents
Ready-to-use solution, 250 μg/mL, in TE buffer (Tris-HCl, 1 mM EDTA, pH 8.0)
CPLA2/PLA2G4A (phospholipase A2, group IVA(cytosolic, calcium-dependent)) is located on human chromosome 1q31.1. cPLA2α is an 85 kDa protein made of 749 amino acids. It is a member of the the α-β hydrolase family. CPLA2 has an N-terminal C2 domain (Ca2+ - dependent, phospholipid binding) and two catalytic domains (α/β hydrolase). This protein is located in the cytoplasm.
特异性
Anti-Phospholipase A2 (cPLA2) (N-terminal), specifically recognizes human cPLA2.
应用
Anti-Phospholipase A2 (cPLA2) (N-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
生化/生理作用
CPLA2/PLA2G4A (phospholipase A2, group IVA(cytosolic, calcium-dependent)) helps to hydrolyze phospholipids at the sn-2-acyl ester bond to generate free fatty acid and lysophospholipid second messengers. It is associated with several diseases like cardiovascular disease, diabetes, asthma and arthritis.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
储存及稳定性
Store at −20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
PLA2G4A (phospholipase A2, group IVA (cytosolic, calcium-dependent))
Linkous A and Yazlovitskaya E
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2010)
Sangita Paul et al.
eNeuro, 9(6) (2022-11-10)
Hyperactivation of cyclin-dependent kinase 5 (Cdk5) by p25, contributes to neuroinflammation causing neurodegeneration in Parkinson's disease (PD) and Alzheimer's disease. However, the mechanism by which Cdk5 induces neuroinflammation in the PD brain is largely unexplored. Here, we show that Cdk5
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