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安全信息

SAB4200190

Sigma-Aldrich

Anti-Sumo-2/3 antibody, Rat monoclonal

clone 3H12, purified from hybridoma cell culture

别名:

Anti-HSMT3, Anti-MGC117191, Anti-SMT3 homolog 2, Anti-SMT3 suppressor of mif two 3 homolog 2, Anti-SMT3B, Anti-SMT3H2, Anti-sentrin 2, Anti-small ubiquitin-like modifier 2, Anti-small ubiquitin-related modifier 2, Anti-ubiquitin-like protein SMT3B, Monoclonal Anti-Sumo-2/3, SUMO-2/3, SUMO2/3

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About This Item

MDL编号:
MFCD03455941
UNSPSC代码:
12352203
NACRES:
NA.41

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

抗体产品类型

primary antibodies

克隆

3H12, monoclonal

表单

buffered aqueous solution

分子量

~11 kDa

种属反应性

mouse, rat, human

浓度

~1.0 mg/mL

技术

immunocytochemistry: suitable
western blot: 2-4 μg/mL using HeLa cell nuclear extract

UniProt登记号

P55854

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... SUMO3(6612)
mouse ... Sumo3(20610)
rat ... Sumo3(499417)

一般描述

Monoclonal Anti-Sumo-2/3 (rat IgG2a isotype) is derived from the hybridoma 3H12 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a human SUMO3 fusion protein.
Small ubiquitin-like modifier 3 (SUMO3) is encoded by the gene mapped to human chromosome 21q22.3. The protein belongs to the ubiquitin-like protein family and is expressed mainly in cytoplasm.

免疫原

human SUMO3 fusion protein

应用

Monoclonal Anti-Sumo-2/3 has been used in immunoblotting and immunocytochemistry.

生化/生理作用

Small ubiquitin-like modifier (SUMO) was identified as a post-translational protein modifier.
Small ubiquitin-like modifier 3 (SUMO3) plays a vital role in enhancing cellular responses to environmental stress. It acts as a key element of the leukemogenic network in transient myeloproliferative disorder (TMD) of the newborn/acute megakaryoblastic leukaemia (AMKL).

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000128396
0000108941
070M4777

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A 15q24 microdeletion in transient myeloproliferative disease (TMD) and acute megakaryoblastic leukaemia (AMKL) implicates PML and SUMO3 in the leukaemogenesis of TMD/AMKL
Haemmerling S
British Journal of Haematology, 157, 180-187 (2012)
The Small Ubiquitin-Like Modifier (SUMO) and SUMO-Conjugating System of Chlamydomonas reinhardtii
Wang Y, et al.
Genetics, 179(1), 177-177 (2008)
SUMO-2/3 conjugates accumulating under heat shock or MG132 treatment result largely from new protein synthesis.
Castoralova M
Biochimica et Biophysica Acta, 1823, 911-919 (2012)
Molecular features of human ubiquitin-like SUMO genes and their encoded proteins
Su HL and Li SS
Gene, 296, 65-73 (2002)
Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.
Saitoh H and Hinchey J.
The Journal of Biological Chemistry, 275, 6252-6258 (2000)
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