SAB4200182
Anti-Glutathione Reductase antibody, Mouse monoclonal
clone GR6, purified from hybridoma cell culture
别名:
Anti-GR, Anti-GSR, Anti-Glutathione-disulfide reductase, Anti-NADPH:oxidized glutathione oxidoreductase
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关于此项目
Conjugate:
unconjugated
Clone:
GR6, monoclonal
Application:
immunoprecipitation (IP)
western blot
western blot
Species reactivity:
human
Citations:
4
Technique(s):
immunoprecipitation (IP): suitable
western blot: 2-4 μg/mL using whole extracts of human HepG2 cells.
western blot: 2-4 μg/mL using whole extracts of human HepG2 cells.
Uniprot accession no.:
产品名称
Anti-Glutathione Reductase antibody, Mouse monoclonal, clone GR6, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
GR6, monoclonal
form
buffered aqueous solution
mol wt
antigen ~55 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): suitable
western blot: 2-4 μg/mL using whole extracts of human HepG2 cells.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GSR(2936)
Application
Monoclonal Anti-Glutathione Reductase antibody produced in mouse has been used in:
- immunohistochemical
- immunofluorescence studies
- immunoblotting
- immunoprecipitation
Biochem/physiol Actions
Glutathione reductase (GR) is a ubiquitous flavoenzyme involved in protecting cells from stress. GR catalyses the reduction of oxidized glutathione (GSSG) to glutathione (GSH). It is an essential component of the glutathione redox cycle, which maintains adequate levels of reduced cellular GSH. GSH serves as an antioxidant and also as an electron donor for glutathione peroxidases and a substrate for glutathione-S-transferases.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-Glutathione Reductase (mouse IgG1 isotype) is derived from the hybridoma GR6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a human Glutathione reductase recombinant protein. Glutathione reductase is a homodimeric enzyme containing one FAD molecule and NADPH binding domain per subunit. This gene is located on human chromosome 8p.
Immunogen
mice immunized with a human Glutathione reductase recombinant protein. The corresponding proteins in rat and mouse share 86% and 85% homology, respectively.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Electrostatic control of the isoalloxazine environment in the two-electron reduced states of yeast glutathione reductase
Picaud T and Desbois A
The Journal of Biological Chemistry, 277(35), 31715-31721 (2002)
Inverted tandem duplication of 8p12-p23. 1 in a child with increased activity of glutathione reductase.
Nevin NC, et al.
Journal of medical Genetics, 27(2), 135-136 (1990)
Inherited glutathione reductase deficiency and Plasmodium falciparum malaria?a case study
Gallo V, et al.
Testing, 4(10), e7303-e7303 (2009)
The effect of glucagon-like peptide-1 in the management of diabetes mellitus: cellular and molecular mechanisms.
Lotfy M, et al.
Cell and Tissue Research, 358(2), 343-358 (2014)
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