推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~30 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
western blot: 0.25-0.5 μg/mL using whole extracts of HEK-293T cells over expressing human Atg101
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... C12orf44(60673)
一般描述
Autophagy101 (Atg101) is located on the human chromosome at 12q13.13.
应用
Anti-Atg101 antibody has been used in
- immunoblotting
- immunofluorescence
- immunopurification
生化/生理作用
Autophagy101 (Atg101) is a mammalian Autophagy13 (Atg13) binding protein essential for autophagy. Atg13 forms a stable complex with ULK1 (Serine/threonine-protein kinase ULK1) and FIP200 (FAK family kinase-interacting protein of 200 kDa). Atg101 associates with the ULK1-Atg13- FIP200 complex through direct interaction with Atg13. Mammalian target of rapamycin (mTOR) interacts with the ULK1-Atg13-FIP200 complex in a nutrient dependent manner, suggesting that mTOR regulates autophagy through this complex.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells
Hieke N, et al.
Autophagy, 11(9), 1471-1483 (2015)
Molecular Machinery and Genetics of the Autophagy Pathway
Autophagy in health and disease, 16-16 (2012)
Mei Yang et al.
Science advances, 2(9), e1601167-e1601167 (2016-09-13)
The intronic GGGGCC hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) is a prevalent genetic abnormality identified in both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Smith-Magenis syndrome chromosomal region candidate gene 8 (SMCR8) is a
Systematic analysis of ATG13 domain requirements for autophagy induction
Wallot-Hieke N, et al.
Autophagy, 14(5), 743-763 (2018)
Benjamin J Ravenhill et al.
Molecular cell, 74(2), 320-329 (2019-03-12)
Xenophagy, a selective autophagy pathway that protects the cytosol against bacterial invasion, relies on cargo receptors that juxtapose bacteria and phagophore membranes. Whether phagophores are recruited from a constitutive pool or are generated de novo at prospective cargo remains unknown. Phagophore
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