SAB4200145
Anti-AMSH-LP/STAMBPL1 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-ALMalpha, Anti-AMSH-FP, Anti-AMSH-like protease, Anti-STAM binding protein-like 1, Anti-associated molecule with the SH3 domain of STAM (AMSH) like protein
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所有图片(2)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.41
推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~50 kDa
种属反应性
human
包装
antibody small pack of 25 μL
浓度
~1.0 mg/mL
技术
indirect immunofluorescence: 2-5 μg/mL using human HeLa cells
western blot: 1-2 μg/mL using whole extracts of human PMC2 cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... STAMBPL1(57559)
一般描述
STAM binding protein like 1 (STAMBPL1) or AMSH-LP (AMSH-like protein), is a close homolog of AMSH (Associated Molecule with the SH3 domain of STAM). AMSH and AMSH-LP belong to the Joseph disease protease and JAB1/MPN/Mov34 metalloenzyme (JAMM) domain metalloprotease family of Zn2+-dependent deubiquitinating enzymes (DUBs). STAMBPL1 is mapped to human chromosome 10q23.31.
特异性
Anti-AMSH-LP/STAMBPL1 recognizes human AMSH-LP/STAMBPL1.
应用
Anti-AMSH-LP/STAMBPL1 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生化/生理作用
STAM binding protein like 1 (STAMBPL1), along with Associated Molecule with the SRC homology 3 domain (SH3) of STAM (AMSH proteins) mediate the deubiquitination of endosomal proteins and specifically cleave lysine-63-linked polyubiquitin chains. AMSH-LP, like AMSH, interacts with clathrin heavy chain and this interaction is essential for its endosomal localization. However, AMSH-LP, unlike AMSH, fails to bind to the SH3 domain of STAM, suggesting that they are not functionally redundant. AMSH-LP positively regulates transforming growth factor (TGF-β) signaling through interaction with inhibitory I-SMADs.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
储存及稳定性
Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling
Ibarrola N, et al.
BMC Cell Biology, 5(1), 2-2 (2004)
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains
Sato Y, et al.
Nature, 455(7211), 358-362 (2008)
Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes
Nakamura M, et al.
Genes Cells, 11(6), 593-606 (2006)
Chinyere Ibeawuchi et al.
International journal of molecular sciences, 16(2), 3856-3869 (2015-02-14)
The multifocal nature of prostate cancer (PCa) creates a challenge to patients' outcome prediction and their clinical management. An approach that scrutinizes every cancer focus is needed in order to generate a comprehensive evaluation of the disease, and by correlating
Xi Chen et al.
Cancer letters, 456, 49-58 (2019-04-21)
The zinc metalloprotease STAM-binding protein-like 1 (STAMBPL1) has been identified as a deubiquitinase by specifically cleaving Lys-63-linked polyubiquitin chains, but its cellular function remains unclear. Here we described the potential role of STAMBPL1 in suppression of the intrinsic apoptosis. We
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