Anti-FIP200 (C-terminal) antibody produced in rabbit

FIP200 (focal adhesion kinase family interacting protein of 200 kDa), also known as RB1CC1 (retinoblastoma 1-inducible coiled-coil 1), is a multifunctional protein. It is mainly localized in the cytoplasm. The FIP200 gene is mapped to human chromosome 8q11.23.

Anti-FIP200 (C-terminal) recognizes human FIP200.

Anti-FIP200 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Focal adhesion kinase family interacting protein of 200 kDa (FIP200) interacts with UNC-51-like kinase (ULK 1) and is essential for autophagy. It also interacts with Pyk2 (proline-rich tyrosine kinase 2), FAK (focal adhesion kinase), TSC1 (TSC complex subunit 1), p53, apoptosis signal-regulating kinase 1 (ASK1) and TRAF2 (TNF receptor associated factor 2) and regulates cell growth, cell proliferation, cell survival, cell adhesion and cell migration. Deficiency in FIP200 is associated with embryonic death and cancer development.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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