生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~50 kDa
种属反应性
human
包装
antibody small pack of 25 μL
浓度
~1 mg/mL
技术
western blot: 1-2 μg/mL using whole extracts of human U87 cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ULK3(25989)
一般描述
Anti-ULK3 is produced in rabbit using as the immunogen a synthetic peptide corresponding to a fragment of human ULK3, conjugated to KLH. Unc-51-like kinase 3 (ULK3) belongs to the ULK family of serine/threonine kinases. ULK3 is an autophagy related protein with an N-terminal kinase domain, which shows high similarity to those of ULK1 and ULK2. ULK3 localizes to the elongating isolation membrane upon autophagy activation.
应用
Anti-ULK3 antibody produced in rabbit has been used in immunoblotting.
生化/生理作用
Unc-51-like kinase 3 (ULK3) controls abscission timing in response to lagging chromosomes. Overexpression of ULK3 induces autophagy and senescence. ULK3 is also a positive regulator of the Hedgehog signalling pathway.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
mTOR regulation of autophagy
Jung CH, et al.
Febs Letters, 584(7), 1287-1295 (2010)
The ULK1 complex: sensing nutrient signals for autophagy activation
Wong PM, et al.
Autophagy, 9(2), 124-137 (2013)
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
Sulli G, et al.
Nature, 553(7688), 351-351 (2018)
The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI
Goruppi , et al.
Testing, 20(10), 2468-2479 (2017)
Gabriele Sulli et al.
Nature, 553(7688), 351-355 (2018-01-11)
The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer and chronic circadian rhythm disruption predisposes individuals to tumour development. This raises the hypothesis that pharmacological modulation
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