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生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~48 kDa
种属反应性
human
增强验证
recombinant expression
Learn more about Antibody Enhanced Validation
浓度
~1.5 mg/mL
技术
western blot: 1-2 μg/mL using lysates of HEK-293T cells overexpressing human DYX1C1
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... DYX1C1(161582)
一般描述
Anti-DYX1C1 (N-terminal) is produced in rabbit using as the immunogen a synthetic peptide corresponding to a sequence at the N-terminal of human DYX1C1, conjugated to KLH. DYX1C1 is expressed in brain and the protein resides in the nucleus.
DYX1C1/dynein axonemal assembly factor 4 (DNAAF4) gene with 10 exons, extending over a length of ~78 kb on genomic DNA, is mapped to human chromosome 15q21.3. DYX1C1 contains a nuclear tetratricopeptide repeat domain.
应用
Anti-DYX1C1 (N-terminal) antibody produced in rabbit has been used in immunoblotting.
Anti-DYX1C1 (N-terminal) antibody produced in rabbit has been used in immunofluorescence studies.
生化/生理作用
DYX1C1 has been recently implicated as a cancer biomarker in colorectal cancer.
DYX1C1/dynein axonemal assembly factor 4 (DNAAF4) plays a vital role in neuronal migration and regulation of estrogen receptor signaling. Mutation in the gene increases the risk of susceptibility to developmental dyslexia (DD). Variations in the gene is also associated with the deficits in reading, orthographic skills and spelling.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
A family-based association study does not support DYX1C1 on 15q21.3 as a candidate gene in developmental dyslexia
Marino C
European Journal of Human Genetics, 13, 491-499 (2005)
Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2.
Bieder, et al.
BMC molecular and cell biology, 24, 20-20 (2023)
Association of SNPs of DYX1C1 with developmental dyslexia in an Indian population.
Venkatesh SK
Psychiatric Genetics, 24, 10-20 (2014)
Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteins.
Tammimies K
Biological Psychiatry, 73, 583-590 (2013)
Molecular characterization of the DYX1C1 gene and its application as a cancer biomarker
Kim YJ, et al.
Journal of Cancer Research and Clinical Oncology, 135(2), 265-270 (2009)
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