推荐产品
生物来源
mouse
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
NX-38, monoclonal
表单
buffered aqueous solution
分子量
antigen 80 kDa
种属反应性
mouse, human, rat
包装
antibody small pack of 25 μL
浓度
~1 mg/mL
技术
immunocytochemistry: suitable
western blot: 1-2 μg/mL using using rat brain S1 fraction extracts
同位素/亚型
IgG2a
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NEXN(91624)
mouse ... Nexn(68810)
rat ... Nexn(246172)
一般描述
Monoclonal Anti-Nexilin (mouse IgG2a isotype) is derived from the hybridoma NX-38 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide conjugated to KLH. Nexilin is a filamentous actin-binding protein that localizes to focal contacts. Alternative splicing of the gene yields two different isoforms namely, b-nexilin and s-nexilin.
NEXN (nexilin), a cardiac Z-disc protein is made of 675 amino acids. It is present in the heart and skeletal muscle. NEXN is mapped to human chromosome 1p31.
特异性
Monoclonal Anti-Nexilin recognizes human, rat, and mouse nexilin.
应用
Anti-Nexilin antibody,Mouse monoclonal may be used in immunoblotting and immunocytochemistry.
生化/生理作用
NEXN (nexilin) plays an important role in protecting cardiac Z-discs from forces generated within the sarcomere. Mutations in NEXN results in hypertrophic cardiomyopathy.
Nexilin may be involved in cell adhesion and migration.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
储存及稳定性
Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
从最新的版本中选择一种：
Mutations in NEXN, a Z-disc gene, are associated with hypertrophic cardiomyopathy.
Wang H, et al.
American Journal of Human Genetics, 87(5), 687-693 (2010)
A novel genetic variant in long non-coding RNA gene NEXN-AS1 is associated with risk of lung cancer.
Yuan H, et al.
Scientific Reports, 6, 34234-34234 (2016)
H T Law et al.
Cellular microbiology, 14(7), 1097-1108 (2012-03-03)
The bacterial pathogens Listeria monocytogenes and enteropathogenic Escherichia coli (EPEC) generate motile actin-rich structures (comet tails and pedestals) as part of their infectious processes. Nexilin, an actin-associated protein and a component of focal adhesions, has been suggested to be involved
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