推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~72 kDa
种属反应性
human
浓度
~1.5 mg/mL
技术
immunohistochemistry: 10-20 μg/mL using formalin-fixed, paraffin-embedded human colon
western blot: 0.5-1.0 μg/mL using HS68 cell extracts
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NOX1(27035)
mouse ... Nox1(237038)
rat ... Nox1(114243)
一般描述
NADPH oxidase 1 (NOX1) is encoded by the gene mapped to human chromosome Xq22.1. The protein belongs to the family of NADPH oxidases and is co-localized with caveolin in punctate patches on the surface and laterally on the cellular margins. NOX1 is mainly expressed in colon epithelium.
应用
Anti-NOX1 antibody produced in rabbit has been used in:
- Immunocytochemistry.
- Immunoprecipitation
- Immunoblotting.
Anti-NOX1 antibody produced in rabbit may be used in immunofluorescence and immunohistochemistry.
生化/生理作用
NADPH oxidase 1 (NOX1) requires two cytosolic regulators NADPH oxidase activator 1(NOXA1) and NADPH oxidase organizer 1 (NOXO1) as well as Ras-related C3 botulinum toxin substrate 1 (Rac1) for its activity. NOX1 and NOX2 promote neurotoxic activation of microglia suggesting that they play a central role during neuroinflammatory states and in amyotrophic lateral sclerosis (ALS). In ALS mice deletion of either NOX1 and NOX2 gene have been shown to significantly slowed disease progression and improved survival.
NOX1 catalyzes the production of hydrogen peroxide (H2O2). Overexpression of the protein leads to the production of both superoxide and H2O2 and triggers angiogenic switch, mediating vascularization and rapid expansion of the tumor. Elevated expression of NOX1 has been observed in the brain of Parkinson′s disease (PD) patients.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Reactive oxygen generated by Nox1 triggers the angiogenic switch
Arbiser JL
Proceedings of the National Academy of Sciences of the USA, 99, 715-720 (2002)
Involvement of Rac1 in activation of multicomponent Nox1-and Nox3-based NADPH oxidases
Ueyama T, et al.
Molecular and cellular biology, 26(6), 2160-2174 (2006)
Anthony J Valente et al.
Cellular signalling, 25(6), 1447-1456 (2013-04-02)
We investigated the role of TRAF3 interacting protein 2 (TRAF3IP2), a redox-sensitive adapter protein and an upstream regulator of IKK and JNK in interleukin (IL)-18 induced smooth muscle cell migration, and the mechanism of its inhibition by simvastatin. The pleiotropic
NADPH oxidases in Parkinson's disease: a systematic review.
Belarbi K
Mol. Neurodegener., 12 (2017)
ROS production as a common mechanism of ENaC regulation by EGF, insulin, and IGF-1
Ilatovskaya DV
American Journal of Physiology. Cell Physiology, 304, C102-C111 (2013)
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