生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~66 kDa
种属反应性
mouse, rat, human
包装
antibody small pack of 25 μL
浓度
~1.5 mg/mL
技术
indirect immunofluorescence: 5-10 μg/mL using HS68 cells
western blot: 1.5-3.0 μg/mL using PC12 cell extracts and mouse brain extracts (S1 fraction)
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CORO1B(57175)
一般描述
Coronin 1B (CORO1B) is encoded by the gene mapped to human chromosome 11q13.2. CORO1B belongs to the mammalian coronin gene family. The encoded protein is ubiquitously expressed and is mainly present on the leading edge of migrating fibroblasts.
Coronin-1B localizes to sub-membrane areas.
应用
Anti-Coronin 1B antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生化/生理作用
Coronin 1B (CORO1B) acts as an actin binding protein. It also plays a major role in controlling whole-cell motility and lamellipodial dynamics. CORO1B also influence neurite outgrowth in a neuronal regeneration model. The encoded protein antagonizes a filament branch stabilizer, cortactin and disassembles actin-related protein (Arp) 2/3-containing actin filament branches by promoting Arp2/3 dissociation.
Coronin-1B has been shown to affect cell motility by regulation of actin-depolymerizing factor (ADF)/cofilin proteins at the leading edge. It targets the cofilin-activating phosphatase slingshot-1L to the leading edge, and thus indirectly regulates cofilin activity.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
F-actin binding is essential for coronin 1B function in vivo.
Cai L
Journal of Cell Science, 120, 1779-1790 (2007)
Coronin 1B Coordinates Arp2/3 Complex and Cofilin Activities at the Leading Edge
Cai L
Cell, 128, 915-929 (2007)
Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
Cai L
The Journal of Biological Chemistry, 280, 31913-31923 (2005)
Coronin 1B Antagonizes Cortactin and Remodels Arp2/3-Containing Actin Branches in Lamellipodia
Cai L
Cell, 134, 828-842 (2008)
Searching for the Molecular
Pathways Regulating Bone
Mineral Density in the Proteome
and RNA Interference Era
Pathways Regulating Bone
Mineral Density in the Proteome
and RNA Interference Era
Saad FA
Journal of Orthopedics & Rheumatology, 1 (2013)
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