Monoclonal Anti-PAX9 antibody produced in rat

Monoclonal Anti-PAX9 (rat IgG1 isotype) is derived from the hybridoma paired box 9 (PAX9) 7C2 produced by the fusion of mouse myeloma cells (P3X63Ag8.653) and splenocytes from rat immunized with a recombinant fragment corresponding to a fragment of mouse PAX9 coupled to myelin basic protein (MBP). The PAX gene family encodes a group of transcription factors containing a 128-aa paired DNA-binding domain, and in some cases, a paired-type homeodomain. Nine PAX genes (PAX1-PAX9) has been observed in mammals. Pax9 and Pax1 show high similarities. Pax9 is found in all vertebrates including chick, zebrafish, mouse and man.

Monoclonal Anti-PAX9 antibody produced in rat has been used immunoblotting and immunohistochemistry.

Paired box 9 (PAX9) protein is known to play a role in the formation of various organs and skeletal elements. Mutations in either the PAX1 or the PAX9 genes may produce an inherited skeletal disorder such as the Jarcho-Levin syndrome. Interestingly, progressive loss of PAX9 expression was correlated with increasing malignancy of dysplastic and cancerous epithelium of human esophagus and lung cancer.

Anti-PAX9, paired box 9, is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal de

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

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