生物来源
rat
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
BOP 6H11, monoclonal
表单
buffered aqueous solution
分子量
antigen ~100 kDa
种属反应性
human
包装
antibody small pack of 25 μL
浓度
~1.0 mg/mL
技术
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 0.5-1.0 μg/mL using HeLa cell extracts
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... BOP1(23246)
一般描述
Monoclonal Anti- BOP1 (rat IgG1 isotype) is derived from the hybridoma BOP 6H11 produced by the fusion of mouse myeloma cells (P3X63Ag8.653) and splenocytes from rat immunized with a peptide corresponding to a fragment of human BOP1, coupled to ovalbumin.
应用
Monoclonal Anti-BOP1 antibody produced in rat has been used in several immunochemical techniques including immunoblotting, immunoprecipitation, and immunocytochemistry.
生化/生理作用
Ribosome biogenesis protein BOP1 is an essential component of A nucleolar complex, PeBoW that is involved in ribosome biogenesis and cell proliferation. Fluctuations in Bop1 protein level were found to affect the assembly and integrity of the whole PeBoW (Pes1, Bop1, and WDR12) complex. Overexpression of Bop1 mRNA is associated with the development of colorectal cancer.
外形
Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit
Rohrmoser M, et al.
Molecular and Cellular Biology, 27(10), 3682-3694 (2007)
Siqi Li et al.
The Journal of pathology, 254(3), 265-278 (2021-04-03)
Chemoresistance is a major obstacle to the treatment of triple-negative breast cancer (TNBC), which has a poor prognosis. Increasing evidence has demonstrated the essential role of cancer stem cells (CSCs) in the process of TNBC chemoresistance. However, the underlying mechanism
Michael Hölzel et al.
The Journal of cell biology, 170(3), 367-378 (2005-07-27)
Target genes of the protooncogene c-myc are implicated in cell cycle and growth control, yet the linkage of both is still unexplored. Here, we show that the products of the nucleolar target genes Pes1 and Bop1 form a stable complex
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