SAB4200078
Anti-Coronin-1A (N-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody
别名:
Anti-CLABP, Anti-CLIPINA (coronin-like protein A), Anti-CORO1A, Anti-HCORO1, Anti-TACO (tryptophane aspartate-containing coat protein), Anti-p57
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所有图片(1)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.41
推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~57 kDa
种属反应性
mouse, human, rat
浓度
~1.5 mg/mL
技术
western blot: 1.5-3.0 μg/mL using Jurkat cell lysates, or lysates of mouse brain (S1 fraction) or rat spleen (S1 fraction)
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CORO1A(11151)
mouse ... Coro1a(12721)
rat ... Coro1a(155151)
一般描述
Coronin 1A (Coronin-1A) is encoded by the gene mapped to human chromosome 16p11.2. The encoded 57kDa protein, belongs to the coronin family and is mainly expressed in hematopoietic cells. Coronin family of proteins are characterized with a highly conserved N-terminal extension (NE), five canonical WD40 repeats, a C-terminal conserved extension (CE), followed by a unique region (U), and ends with a C-terminal coiled-coil (CC) domain.
应用
Anti-Coronin-1A (N-terminal) antibody produced in rabbit has been used in immunoblotting.
生化/生理作用
Coronin 1A (Coronin-1A) plays a vital role in F-actin stabilization in vitro. It is also involved in phagocytosis by neutrophils and macrophages and in T-cell receptor (TCR)-mediated activation of T lymphocytes. Additionally, it is also implicated in the regulation of activate actin-related protein-2/3 (Arp2/3)-dependent processes. Mutation in the gene has been observed in T cell-deficient, B cell- and natural killer (NK) cell-sufficient (T?B+NK+) severe combined immunodeficiency (SCID) patients.
Coronin-1A also plays a vital role in regulation of leukocyte specific signaling. In T-lymphocytes, coronin-1A facilitates the association of cytoskeleton dynamics to TCRαβ induced cell signaling, chemokine-mediated cell migration and homeostasis. Loss of coronin-1A gene expression in murine T cells leads to reduced ability to respond to chemotactic gradient and decrease in peripheral T cells due to apoptosis.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Coronin-1 is a neurotrophin endosomal effector required for developmental competition for survival
Suo D
Nature Neuroscience, 17, 36-45 (2014)
Coronin-1A Stabilizes F-Actin by Bridging Adjacent Actin Protomers and Stapling Opposite Strands of the Actin Filament
Galkin VE
Journal of Molecular Biology, 376, 607-613 (2008)
Coronin 1 in innate immunity
The coronin family of proteins, 3, 116-123 (2008)
Christina S Yee et al.
The Journal of allergy and clinical immunology, 137(3), 879-888 (2015-10-20)
Coronin-1A (CORO1A) is a regulator of actin dynamics important for T-cell homeostasis. CORO1A deficiency causes T(-)B(+) natural killer-positive severe combined immunodeficiency or T-cell lymphopenia with severe viral infections. However, because all known human mutations in CORO1A abrogate protein expression, the
Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association.
Yee CS
The Journal of Allergy and Clinical Immunology, 137, 879-888 (2016)
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