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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~45 kDa
antigen ~59 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells
indirect immunofluorescence: 1.25-2.5 μg/mL using paraformaldehyde fixed HEK-293T cells
western blot: 0.5-1 μg/mL using lysates of HEK-293T cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PSPC1(55269)
mouse ... Pspc1(66645)
rat ... Pspc1(305910)
一般描述
PSPC1 has two isoforms α and β.
Paraspeckle component 1 (PSPC1) is encoded by the gene mapped to human chromosome 13q12.11. The encoded protein is a member of DBHS (Drosophila Behavior Human Splicing) family of proteins.
应用
Anti-PSPC1 (C-terminal) antibody produced in rabbit has been used in:
- immunoblotting
- ribonucleoprotein immunoprecipitation assay
- immunofluorescence
- immunocytochemistry
生化/生理作用
Paraspeckle component 1 (PSPC1) is involved in the regulation of nuclear receptors such as the progesterone receptor and the thyroid receptor and in a wide range of processes such as splicing and RNA metabolism.
Since paraspeckle component 1 (PSPC1) has lower background nucleoplasmic signal in various cell types compared to other members of DBHS (drosophila behavior human splicing) family of proteins, it is frequently used as a marker for paraspeckles. The encoded protein plays a vital role in regulation of transcription. Deletion of the gene is associated with the hindered psychomotor development, muscle hypotonia, unilateral microphtalmia with ptosis, congenital eye malformation and facial dysmorphic features.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
The Hepatitis Delta Virus accumulation requires paraspeckle components and affects NEAT1 level and PSP1 localization
Scientific Reports, 8(1), 6031-6031 (2018)
Paraspeckles
Cold Spring Harbor Perspectives in Biology, 2 (2010)
AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis
Biology of Reproduction, 90(6), 119-111 (2014)
PSF and p54nrb/NonO-multi-functional nuclear proteins
Febs Letters, 531(2), 109-114 (2002)
P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner
Molecular Biology of the Cell, 16(11), 5304-5315 (2005)
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