推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~83 kDa
种属反应性
human
浓度
~1.5 mg/mL
技术
western blot: 1.5-3.0 μg/mL using SH-SY5Y cell lysates
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
rat ... Slc6a4(25553)
一般描述
Solute carrier family 6 member 4 (SLC6A4), also known as 5-hydroxytryptamine transporter (5-HTT), is an integral membrane protein, encoded by the gene mapped to human chromosome 17q11.2. The encoded protein is a member of SLC6 gene family and is mainly expressed in brain and blood cells.
应用
Anti-Serotonin Transporter (N-terminal) antibody produced in rabbit has been used in western blot analysis and immunohistochemistry.
生化/生理作用
Solute carrier family 6 member 4 (SLC6A4) catalyzes the transport of neurotransmitter serotonin from the synaptic space into presynaptic neurons. It also plays a vital role in mood and anxiety regulation. Mutation on the gene might alter the expression of serotonin (5HT) in the synaptic cleft, which ultimately leads to schizophrenia. Allelic variations in the gene increases the risk of susceptibility to autism and rigid-compulsive behaviors.
The polymorphic promoter region of the serotonin transporter gene serotonin-transporter-linked polymorphic region (5HTTLPR), has been suggested to affect serotonin uptake and may play a role in the pathogenesis of depression, obsessive-compulsive disorder (OCD) and aggressive behavior.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression
Archives of General Psychiatry, 62(5), 537-544 (2005)
Journal of neurochemistry, 137(3), 423-435 (2016-03-01)
The serotonin transporter (SERT) is responsible for high-affinity serotonin (5-HT) uptake from extracellular fluid and is a prominent pharmacological target in the treatment of depression. In recent years, depression has also been linked to immune system activation. Inflammatory conditions can
Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines
PLoS ONE, 11 (2016)
PloS one, 11(10), e0164425-e0164425 (2016-10-08)
Evidence suggests neuroprotective effects of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), on the developed neurons in the adult brain. In contrast, the drug may be deleterious to immature or undifferentiated neural cells, although the mechanism is unclear. Recent investigations
Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets.
American Journal of Medical Genetics, 88, 83-87 (1999)
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