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安全信息

SAB4200034

Sigma-Aldrich

Anti-BMI1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

别名:

Anti-B lymphoma Mo-MLV insertion region 1 homolog, Anti-PCGF4, Anti-Polycomb group RING finger protein 4, Anti-RNF51, Anti-Ring finger protein 51

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous glycerol solution

分子量

antigen ~37 kDa

种属反应性

human

包装

antibody small pack of 25 μL

浓度

~1.0 mg/mL

技术

immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human BMI1
indirect immunofluorescence: 1-2 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human BMI1
western blot: 2-4 μg/mL using lysates of HEK-293T cells over expressing human BMI1

UniProt登记号

P35226

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... BMI1(648)

一般描述

Anti-BMI1 (C-terminal) is produced in rabbit using as the immunogen a synthetic peptide corresponding to a sequence at the C-terminal of human BMI1, conjugated to KLH. The human proto-oncogene BMI1 (also known as polycomb complex protein BMI-1, polycomb group RING finger protein 4, and RING finger protein 51) is a member of the mammalian Polycomb group (Pc-G) genes.

应用

Anti-BMI1 (C-terminal) antibody produced in rabbit has been used in:
  • western blotting
  • immunoprecipitation
  • immunofluorescence

生化/生理作用

BMI1 (Proto-Oncogene, Polycomb Ring Finger) plays an important role as epigenetic gene silencers during development. Elevated expression of BMI1 is associated with many cancers such as mantle cell lymphoma, B-cell non-Hodgkin′s lymphoma, myeloid leukemia, non-small cell lung cancer, colorectal cancer, breast cancer and prostate cancer. BMI1 has been shown to be also required for self-renewal of hematopoietic stem cells and neuronal stem cells. BMI1 knockout in mice results in defects in hematopoiesis, skeletal patterning and neurological functions.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
119K4834

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访问文档库

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
Molofsky AV, et al.
Nature, 425(6961), 962-962 (2003)
Bmi1, stem cells, and senescence regulation
Park IK, et al.
The Journal of Clinical Investigation, 113(2), 175-179 (2004)
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
Park I K, et al.
Nature, 423(6937), 302-302 (2003)
Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways
Datta S, et al.
Cancer Research, 67(21), 10286-10295 (2007)
Zhaocheng Zhang et al.
Cancer research, 74(10), 2869-2881 (2014-04-02)
Emerging evidence suggests that endothelial cell-secreted factors contribute to the pathobiology of squamous cell carcinoma (SCC) by enhancing invasive migration and resistance to anoikis. Here, we report that SCC cells within the perivascular niche have undergone epithelial to mesenchymal transition

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