Anti-HOXD9 antibody produced in rabbit

In vertebrates, there are 39 homeobox (HOX) genes that are organized into four clusters (HOXA-HOXD), located on different chromosomes (7p15, 17q21.2, 12q13, and 2q31). Each cluster contains 9−11 member genes encoding relatively small gene products containing a highly conserved 60-amino-acid region (the homeobox), with DNA-binding activity that contributes to their activity as transcription factors.

Anti-HOXD9 antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Homeobox (HOX) genes are evolutionarily conserved transcription factors, that control important development pathways involved in morphogenesis of the embryo. One of the major functions of HOX genes seems to be the formation of the body plan during embryonic development. In addition to roles in normal development, altered homeobox gene function or expression is implicated in the development of cancers such as leukemias or neoplasms of the breast, prostate, kidney, colon, skin and brain. HOXD9 is involved in the development processes such as patterning of forelimb, axial skeleton and embryonic segmentation. It might promote cell migration, invasion and metastasis in hepatocellular carcinoma. HOXD9 was shown to be involved in the early stages of normal joint development and also in the pathologic process of arthritis.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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