生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~50 kDa
种属反应性
rat, human
浓度
~1.0 mg/mL
技术
immunoprecipitation (IP): 10-20 μg using lysates of rat NRK cells
western blot: 1-2 μg/mL using whole extracts of HEK-293T cells over expressing human VPS4A
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... VPS4A(27183)
mouse ... Vps4a(116733)
rat ... Vps4a(246772)
一般描述
Vacuolar-protein-sorting factor 4A (VPS4A) is an AAAtype ATPase, encoded by the gene mapped to human chromosome 16q22.1. The encoded protein is a member of vacuolar sorting protein family. The protein is characterized by a canonical AAA ATPase cassette followed by an N-terminal MIT (microtubule interacting and trafficking) domain.
应用
Anti-VPS4A antibody produced in rabbit has been used for co-immunoprecipitation and Western blotting.
生化/生理作用
Vacuolar-protein-sorting factor 4A (VPS4A) plays a vital role in lysosomal/endosomal membrane trafficking. It is also involved in the regulation of exosome biogenesis. Downregulated expression of the gene leads to the development of hepatocellular carcinoma (HCC). Thus, VPS4 is considered to be an effective tumor suppressor for HCC. Mutation of the gene leads to defective multivesicular body formation.
外形
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A
Anna Scott
Proceedings of the National Academy of Sciences of the USA (2005)
Disruption of Neurexin 1 Associated with Autism Spectrum Disorder
Hyung-GooKim
Academic Journal of Interdisciplinary Studies (2008)
Exosomes mediate cell contact?independent ephrin-Eph signaling during axon guidance
Jingyi Gong
The Journal of Cell Biology (2016)
A fourth locus for autosomal dominant hypercholesterolemia maps at 16q22.1
Alice M
European Journal of Human Genetics (2010)
Jingyi Gong et al.
The Journal of cell biology, 214(1), 35-44 (2016-06-30)
The cellular release of membranous vesicles known as extracellular vesicles (EVs) or exosomes represents a novel mode of intercellular communication. Eph receptor tyrosine kinases and their membrane-tethered ephrin ligands have very important roles in such biologically diverse processes as neuronal
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