SAB4200016
Anti-SLC9A1 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-APNH, Anti-NHE1, Anti-Na-Li counter transporter, Anti-Porter, Sodium-hydrogen ion, amiloride-sensitive, Anti-Sodium/hydrogen exchanger 1, Anti-Solute carrier family 9, Isoform A1, Anti-Solute carrier family 9, member 1
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所有图片(1)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.41
推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~95 kDa
种属反应性
human
包装
antibody small pack of 25 μL
浓度
~1.0 mg/mL
技术
western blot: 2.5-5.0 μg/mL using whole extract of human platelets
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SLC9A1(6548)
一般描述
The solute carrier family 9 member A1 (SLC9A1) gene is mapped to human chromosome 1p36.11. The encoded protein is widely expressed in many tissues and is localized to the plasma membrane. SLC9A1 is the only isoform found in mammalian cardiomyocytes. This gene encodes a 815 amino acid protein containing 12 transmembrane spanning domain and a cytoplasmic domain with many regulatory sites.
应用
Anti-SLC9A1 antibody produced in rabbit has been used in western blotting.
生化/生理作用
Solute carrier family 9 member A1 (SLC9A1) mediates the electroneutral exchange of Na+-H+ in response to intracellular acidosis. It drives extracellular Na+ uptake in exchange for intracellular H+. SLC9A1 maintains the pH and cell volume regulation of vertebrate cells. It is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters and cell shrinkage.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Sodium-Hydrogen Exchanger Isoform-1 Inhibition: A Promising Pharmacological Intervention for Resuscitation from Cardiac Arrest
Gazmuri R, et al.
Molecules (Basel), 24(9), 1765-1765 (2019)
CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis
Liu Ye, et al.
The Journal of Neuroscience, 33(31), 12656-12669 (2013)
Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule
Parker MD, et al.
Cellular and Molecular Life Sciences, 72(11), 2061-2074 (2015)
Physiological functions and regulation of the Na+/H+ exchanger [NHE1] in renal tubule epithelial cells
Valles PG, et al.
Kidney & Blood Pressure Research, 40(5), 452-466 (2015)
Naoko Fujii et al.
The Journal of biological chemistry, 291(47), 24787-24799 (2016-10-14)
Hypotonic stress decreased claudin-1 and -2 expression levels in renal tubular epithelial HK-2 and Madin-Darby canine kidney cells. Here, we examined the regulatory mechanism involved in this decrease. The hypotonicity-induced decrease in claudin expression was inhibited by the following: SB202190
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