SAB4200008
Anti-DVL3 (N-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Dishevelled-3
产品名称
Anti-DVL3 (N-terminal) antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~95 kDa
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.5 mg/mL
technique(s)
immunoprecipitation (IP): 2.5-5 μg using HEK-293T cell lysate overexpressing human DVL3
western blot: 0.25-0.5 μg/mL using HEK-293T cell lysates overexpressing human DVL3
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DVL3(1857)
Application
Anti-DVL3 (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Anti-DVL3 (N-terminal) specifically recognizes human DVL3.
Dishevelled 3 (DVL3) participates in the wingless-related integration site (Wnt) signaling pathway. It plays a key role in hippocampal neurogenesis regulation. Knockdown of DVL3 has been shown to attenuate the activation of the wnt signaling pathway by Wnt3A. DVL3 functions in redundant pathways with DVL1 and DVL2, and is necessary in normal cardiac, cochlea, and neural tube development in mice. DVL3, like other members of the DVL family, functions upstream of glycogen synthase kinase-3 (GSK3) to modulate the canonical wnt pathway. A frame shift mutation in DVL3 gene is implicated in Robinow syndrome. Allelic variation in the DVL3 gene may be associated with major depressive disorder.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Dishevelled 3 (DVL3) is a phosphoprotein rich in serine and threonine. It is widely expressed in fetal tissues and specifically expressed in various adult tissues. DVL3 gene is mapped to human chromosome 3q27.1
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development
Etheridge SL, et al.
PLoS Genetics, 4(11), e1000259-e1000259 (2008)
Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs
Hanakova K, et al.
Cell communication and signaling : CCS, 17(1), 170-170 (2019)
The dopamine D2 receptor regulates Akt and GSK-3 via Dvl-3
Sutton LP and Rushlow WJ
The International Journal of Neuropsychopharmacology, 15(7), 965-979 (2012)
DVL3 alleles resulting in a- 1 frameshift of the last exon mediate autosomal-dominant Robinow syndrome
White JJ, et al.
American Journal of Human Genetics, 98(3), 553-561 (2016)
Integrating expression-related SNPs into genome-wide gene-and pathway-based analyses identified novel lung cancer susceptibility genes
Wang Y, et al.
International journal of cancer management, 142(8), 1602-1610 (2018)
相关内容
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