推荐产品
生物来源
mouse
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
RND1-A76, monoclonal
表单
aqueous solution
分子量
antigen predicted mol wt 25.9 kDa
种属反应性
human
技术
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... RND1(27289)
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一般描述
RND1, a Rho GTPase, belongs to the family Rnd. The gene is located on human chromosome 12q13.12.
免疫原
RND1 purified recombinant protein
生化/生理作用
Rho family GTPase 1 (RND1) regulates actin cytoskeleton in several cell types. It is implicated in the Sema3E/plexin-D1-induced inhibition of axon outgrowth in cortical neurons. RND1 plays an important role in plexin signaling. It modulates the dynamics of cell growth and survival. Dysregulation of RND1 is associated with tumorigenesis.
外形
Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
含少量动物源组分生物产品
常规特殊物品
Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs)
Wang H, et al.
The Journal of Biological Chemistry, 286(29), 26093-26106 (2011)
Rnd1 and Rnd3 targeting to lipid raft is required for p190 RhoGAP activation
Oinuma I, et al.
Molecular Biology of the Cell, 23(8), 1593-1604 (2012)
RND1 is up-regulated in esophageal squamous cell carcinoma and promotes the growth and migration of cancer cells
Xiang G, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(1), 773-779 (2016)
David Rizzo et al.
American journal of hematology, 88(9), 747-753 (2013-06-05)
It has recently been suggested that the percentage of smudge cells on blood smears from patients with chronic lymphocytic leukemia (CLL) could predict overall survival. However, smudge cells are a cytological artifact influenced by multiple physical factors not related to
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