生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
human
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TICAM1(148022)
一般描述
Toll like receptor adaptor molecule 1 (TICAM1) is ubiquitously expressed and possesses an N-terminal proline-rich domain, a TIR (Toll/interleukin-1 receptor) motif and a C-terminal proline-rich domain. The gene encoding this protein is localized on human chromosome 19p13.3.
免疫原
Synthetic peptide from human TICAM1 / TRIF.
生化/生理作用
Toll like receptor adaptor molecule 1 (TICAM1) plays a crucial role as an adaptor molecule and links toll-like receptor 3 (TLR3) to interferon-β (IFN-β) promoter activation. It is also involved in IFN-β production. TICAM-1 pathway has an essential role in host protection and innate immune responses against poliovirus (PV) infection. Mutations in the gene have been associated with the development of papillary thyroid cancer, follicular thyroid cancer and differentiated thyroid cancer.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Selected single-nucleotide polymorphisms in FOXE1, SERPINA5, FTO, EVPL, TICAM1 and SCARB1 are associated with papillary and follicular thyroid cancer risk: replication study in a German population.
Sigurdson AJ
Carcinogenesis (2016)
The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.
Oshiumi H
Journal of Immunology (2011)
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.
Oshiumi H
Nature Immunology (2003)
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