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安全信息

SAB2106753

Sigma-Aldrich

Anti-GOLIM4 antibody produced in rabbit

affinity isolated antibody

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UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

75 kDa

种属反应性

dog, rabbit, mouse, human, horse, rat, bovine, guinea pig

浓度

0.5 mg - 1 mg/mL

技术

western blot: suitable

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

一般描述

Golgi internal membrane protein 4 (GOLIM4) is a golgi type II transmembrane phosphoprotein. In human chromosome, the gene GOLIM4 is located on 3q26.2.

免疫原

The immunogen for anti-GOLIM4 antibody: synthetic peptide derected towards the C terminal of human GOLIM4

生化/生理作用

Golim4 plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. Golim4 plays a major role in maintaining manganese homeostasis. The expression level of Golim4 is less in cancer cells. GOLIM4 is a potential oncogene, regulates cell cycle and apoptosis in neck and cancer cells.

序列

Synthetic peptide located within the following region: DPGNRQEFHEPGHQEGDPEAEADRAAAQDINPADDPNNQGEDEFEEAEQV

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Mitochondrial DNA plasticity is an essential inducer of tumorigenesis
Lee WTY, et al.,
Cell death discovery, 2(9), 16016-16016 (2016)
Golgi integral membrane protein 4 manipulates cellular proliferation, apoptosis, and cell cycle in human head and neck cancer
Bai Y, et al.
Bioscience Reports, 38(4), BSR20180454-BSR20180454 (2018)
Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies
Lancet Neurology, 13(9), 893-893 (2014)
Matthew L Hemming et al.
PloS one, 4(12), e8477-e8477 (2009-12-31)
Beta-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease with a lumenal active site that sheds the ectodomains of membrane proteins through juxtamembrane proteolysis. BACE1 has been studied principally for its role in Alzheimer's disease as the beta-secretase

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