生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~12.32 kDa
种属反应性
human
技术
immunofluorescence: suitable
western blot: 1 μg/mL
NCBI登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... KIAA0101(9768)
一般描述
KIAA0101, also known as, proliferating cell nuclear antigen (PCNA) clamp associated factor (PCLAF), is a proliferating cell nuclear antigen-associated factor. It is a 15kDa protein. It is highly expressed in thymus and colon. KIAA0101 gene is located on the human chromosome 15q22.31.
免疫原
KIAA0101 (NP_055551.1, 1 a.a. ~ 111 a.a) full-length human protein.
Sequence
MVRTKADSVPGTYRKVVAARAPRKVLGSSTSATNSTSVSSRKAENKYAGGNPVCVRPTPKWQKGIGEFFRLSPKDSEKENQIPEEAGSSGLGKAKRKACPLQPDHTNDEKE
Sequence
MVRTKADSVPGTYRKVVAARAPRKVLGSSTSATNSTSVSSRKAENKYAGGNPVCVRPTPKWQKGIGEFFRLSPKDSEKENQIPEEAGSSGLGKAKRKACPLQPDHTNDEKE
生化/生理作用
KIAA0101, also known as, proliferating cell nuclear antigen (PCNA) clamp associated factor (PCLAF), helps in regulating DNA repair, cell cycle progression and cell proliferation. Overexpression of KIAA0101 inhibits UV-induced cell death. It is also used as a prognostic marker for hepatocellular carcinoma(HCC). Overexpression of KIAA0101 acts as a marker for adrenocortical carcinoma (ACC) and human gastric cancer.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signals
Kulsk JK, et al.
Journal of Molecular Medicine, 83(12), 964-975 (2005)
KIAA0101 is overexpressed, and promotes growth and invasion in adrenal cancer
Jain M, et al.
PLoS ONE, 6(11), e26866-e26866 (2011)
Overexpression of KIAA0101 predicts high stage, early tumor recurrence, and poor prognosis of hepatocellular carcinoma
Yuan RH, et al.
Clinical Cancer Research, 13(18), 5368-5376 (2007)
Kun Zhu et al.
Cancer science, 104(3), 353-359 (2012-12-18)
Gastric cancer (GC) is one of the most common malignant tumors with a high rate of recurrence, which results in surgery being unsuccessful. Therefore, it is important to find the reason for the surgery failing. The purpose of the present
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