推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~24.4 kDa
种属反应性
human
技术
western blot: 1 μg/mL
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... RAB11A(8766)
一般描述
Ras-related protein Rab-11A (RAB11A), member RAS oncogene family, is a GTP binding protein. RAB11A gene is located on human chromosome 15q21.3. RAB11A is expressed abundantly in tissues with high secretion.
免疫原
RAB11A (NP_004654.1, 1 a.a. ~ 216 a.a) full-length human protein.
Sequence
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
Sequence
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
生化/生理作用
Ras-related protein Rab-11A (RAB11A), member RAS oncogene family, is involved in vesicle trafficking during recycling of endosomes. Overexpression of RAB11A leads to an increased collective cell invasion in colorectal carcinoma.RAB11A and its binding partners plays a crucial role in recycling of human β1-adrenergic receptor.
外形
Solution in phosphate buffered saline, pH 7.4
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Rab11a and its binding partners regulate the recycling of the ss1-adrenergic receptor
Gardner LA, et al.
Cellular Signalling, 23(1), 46-57 (2011)
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma
Chung YC, et al.
European Journal of Clinical Investigation, 46(12), 1002-1011 (2016)
c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis
Gebhardt C, et al.
The American Journal of Pathology, 167(1), 243-253 (2005)
Molecular mechanism of constitutively active Rab11A was revealed by crystal structure of Rab11A S20V
Choi JY, et al.
Febs Letters, 590(6), 819-827 (2016)
Kazumori Kawakami et al.
Oncology reports, 16(3), 521-531 (2006-07-26)
Large-scale gene expression profiling is an effective strategy for understanding the progression of bladder cancer (BC). The aim of this study was to identify genes that are expressed differently in the course of BC progression and to establish new biomarkers
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