推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~48.3 kDa
种属反应性
human
技术
indirect immunofluorescence: suitable
western blot: 1 μg/mL
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... FASN(2194)
一般描述
FASN (fatty acid synthase) encodes a fatty acid synthase (FAS) enzyme. This gene is located on human chromosome 17.
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-α (ER-α), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-α. (provided by RefSeq)
免疫原
FASN (AAH07909.1, 1 a.a. ~ 439 a.a) full-length human protein.
Sequence
MSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG
Sequence
MSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG
生化/生理作用
FASN (fatty acid synthase) is essential for de novo fatty-acid synthesis. It plays a major role in glioma neovascularization. The product of this gene helps in the production of fatty acids from acetyl-CoA and malonyl-CoA. Absence of FASN may block migration, invasion and healing of hepatoma carcinoma cells by reducing HIF-1α (hypoxia-inducible factor 1-α) and IGFBP1 (insulin-like growth factor binding protein-1).
外形
Solution in phosphate buffered saline, pH 7.4
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model.
Bastos DC, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 97(2), 194-194 (2017)
FASN, dietary fat intake, and risk of uterine leiomyomata in the Black Women's Health Study
Wise LA, et al.
Fertility and Sterility, 106(5), 1136-1141 (2016)
Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1?/IGFBP1 pathway
Gong J, et al.
International Journal of Oncology, 50(3), 883-892 (2017)
Inhibition of fatty acid synthase suppresses neovascularization via regulating the expression of VEGF-A in glioma
Zhou Y, et al.
Journal of Cancer Research and Clinical Oncology, 142(12), 2447-2459 (2016)
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