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生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
4D9, monoclonal
形式
buffered aqueous solution
分子量
antigen ~37 kDa
种属反应性
human
技术
ELISA: suitable
capture ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: 1-5 μg/mL
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... FZD7(8324)
一般描述
Frizzled class receptor 7 (FZD7) is an oncogene involved in various malignancies. It is a receptor of Wingless (WNT) proteins. The protein possesses seven hydrophobic domains. The gene encoding FZD7 is localized on human chromosome 2q33.1.
免疫原
FZD7 (NP_003498.1, 155 a.a. ~ 253 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
GAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFA
Sequence
GAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFA
生化/生理作用
Frizzled class receptor 7 (FZD7) modulates sensitivity to chemotherapeutic drugs. It functions in tumor initiation in melanoma cells. The protein acts as a mediator in canonical and non-canonical Wnt signaling pathways.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
The Frizzled family: receptors for multiple signal transduction pathways
Hui-Chan Huang
Genome Biology (2004)
Comparative integromics on FZD7 orthologs: conserved binding sites for PU. 1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs
Masuko Katoh
International Journal of Molecular Medicine (2007)
FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway
M Asad
Cell Death & Disease (2014)
FRIZZLED7 Is Required for Tumor Inititation and Metastatic Growth of Melanoma Cells
Shweta T
PLoS ONE (2016)
Knockdown of frizzled-7 inhibits cell growth and metastasis and promotes chemosensitivity of esophageal squamous cell carcinoma cells by inhibiting Wnt signaling.
Liu X
Biochemical and Biophysical Research Communications (2017)
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