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安全信息

SAB1401818

Sigma-Aldrich

Anti-WDR77 antibody produced in rabbit

whole antiserum, buffered aqueous solution

别名:

HKMT1069, MEP50, MGC2722, Nbla10071, RP11-552M11.3, p44

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

100

偶联物

unconjugated

抗体形式

whole antiserum

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

种属反应性

human

技术

western blot: 1:500-1:1000

NCBI登记号

NM_024102.2

UniProt登记号

Q9BQA1

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... WDR77(79084)

一般描述

WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM

免疫原

WDR77 (NP_077007.1, 1 a.a. ~ 342 a.a) full-length human protein.

Sequence
MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE

生化/生理作用

WD repeat domain 77 (WDR77) associates with protein arginine methyltransferase 5 (PRMT5) in a methylosome complex and stimulates its histone methyltransferase activity. It also binds to androgen receptors and modulates its target genes in prostate epithelial cells and prostate cancer.

外形

Clear solution

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
09243

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访问文档库

Subcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells.
Gao S and Wang Z
PLoS ONE, 7(11), e49173-e49173 (2012)
The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond.
Stopa N
Cellular and Molecular Life Sciences, 72(11), 2041-2059 (2015)

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