产品名称
Anti-RAC3 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RAC3(5881)
Biochem/physiol Actions
Rac family small GTPase 3 (RAC3) helps in intracellular signalling. RAC3 activity is regulated by breakpoint cluster region (Bcr). Rac3 is a potential therapeutic target for lung adenocarcinoma. Rac3 acts as a negative regulator of autophagy.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Rac family small GTPase 3 (RAC3) gene is located on human chromosome 17q25.3. RAC3 is expressed in neurons of ganglia and the central nervous system.
Immunogen
RAC3 (NP_005043.1, 1 a.a. ~ 192 a.a) full-length human protein.
Sequence
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKPGKKCTVF
Sequence
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKPGKKCTVF
Physical form
Solution in phosphate buffered saline, pH 7.4
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
A role for the Rac3 GTPase in autophagy regulation
Zhu, Wan et al.
The Journal of biological chemistry, jbc-M111 (2011)
Rac3 regulates cell proliferation through cell cycle pathway and predicts prognosis in lung adenocarcinoma
Wang, Ge et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(9), 12597-12607 (2016)
The small GTPase RAC3 gene is located within chromosome band 17q25. 3 outside and telomeric of a region commonly deleted in breast and ovarian tumours
Morris CM, et al.
Cytogenetic and genome research, 89(1-2), 18-23 (2000)
Characterization of RAC3, a novel member of the Rho family
Haataja L, et al.
Test, 272(33), 20384-20388 (1997)
GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
Bustelo, et al.
Bioessays, 29(4), 356-370 (2007)
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