生物来源
rabbit
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
human
技术
western blot: 1 μg/mL
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... RAC3(5881)
一般描述
Rac family small GTPase 3 (RAC3) gene is located on human chromosome 17q25.3. RAC3 is expressed in neurons of ganglia and the central nervous system.
免疫原
RAC3 (NP_005043.1, 1 a.a. ~ 192 a.a) full-length human protein.
Sequence
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKPGKKCTVF
Sequence
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKPGKKCTVF
生化/生理作用
Rac family small GTPase 3 (RAC3) helps in intracellular signalling. RAC3 activity is regulated by breakpoint cluster region (Bcr). Rac3 is a potential therapeutic target for lung adenocarcinoma. Rac3 acts as a negative regulator of autophagy.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
A role for the Rac3 GTPase in autophagy regulation
Zhu, Wan et al.
The Journal of biological chemistry, jbc-M111 (2011)
Rac3 regulates cell proliferation through cell cycle pathway and predicts prognosis in lung adenocarcinoma
Wang, Ge et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(9), 12597-12607 (2016)
The small GTPase RAC3 gene is located within chromosome band 17q25. 3 outside and telomeric of a region commonly deleted in breast and ovarian tumours
Morris CM, et al.
Cytogenetic and genome research, 89(1-2), 18-23 (2000)
A role for the Rac3 GTPase in autophagy regulation
Zhu, Wan et al.
The Journal of Biological Chemistry, jbc-M111 (2011)
GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
Bustelo, et al.
Bioessays, 29(4), 356-370 (2007)
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