生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
human
技术
immunofluorescence: suitable
western blot: 1 μg/mL
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NXN(64359)
一般描述
NXN (Nucleoredoxin) is a novel cell growth regulatory protein belonging to the thioredoxin (TRX) family. It has a molecular mass of 55kDa. It is expressed in several adult tissues and is predominantly localized in the nucleus. It consists of a conserved TRX domain and a catalytic region, which exerts oxidoreductase activity.
免疫原
NXN (NP_071908, 1 a.a. ~ 435 a.a) full-length human protein.
Sequence
MSGFLEELLGEKLVTGGGEEVDVHSLGARGISLLGLYFGCSLSAPCAQLSASLAAFYGRLRGDAAAGPGPGAGAGAAAEPEPRRRLEIVFVSSDQDQRQWQDFVRDMPWLALPYKEKHRKLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVNDFLAEKLKPEPI
Sequence
MSGFLEELLGEKLVTGGGEEVDVHSLGARGISLLGLYFGCSLSAPCAQLSASLAAFYGRLRGDAAAGPGPGAGAGAAAEPEPRRRLEIVFVSSDQDQRQWQDFVRDMPWLALPYKEKHRKLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVNDFLAEKLKPEPI
生化/生理作用
NXN (Nucleoredoxin) is associated with several regulatory cellular processes such as regulation of Wnt/β-catenin pathway, oxidative stress responses. It acts as a thiol reductase and reactive oxygen species regulator during thiol-mediated oxidoreduction process. NXN possesses specific binding affinity for protein phosphatase 2A (PP2A). It interacts directly to the catalytic subunit of PP2A during phosphatase activity. It has also been reported that NXN may be involved in the transcriptional regulation of NF-κβ, AP-1, and CREB activation in HEK293 cells.
外形
Solution in phosphate buffered saline, pH 7.4
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闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
K Hirota et al.
Biochemical and biophysical research communications, 274(1), 177-182 (2000-07-25)
Well-established mechanisms for regulation of protein activity include thiol-mediated oxidoreduction in addition to protein-protein interactions and phosphorylation. Nucleoredoxin (NRX), glutaredoxin (GRX), and thioredoxin (TRX) have been shown to act as a potent thiol reductase and reactive oxygen species regulator. They
H Kurooka et al.
Genomics, 39(3), 331-339 (1997-02-01)
In a yeast artificial chromosome contig close to the nude locus on mouse chromosome 11, we identified a novel gene, nucleoredoxin, that encodes a protein with similarity to the active site of thioredoxins. Nucleoredoxin is conserved between mammalian species, and
Yosuke Funato et al.
Antioxidants & redox signaling, 9(8), 1035-1057 (2007-06-15)
Thioredoxin (TRX) family proteins are involved in various biologic processes by regulating the response to oxidative stress. Nucleoredoxin (NRX), a relatively uncharacterized member of the TRX family protein, has recently been reported to regulate the Wnt/beta-catenin pathway, which itself regulates
Katarzyna Lechward et al.
FEBS letters, 580(15), 3631-3637 (2006-06-13)
A trimeric protein phosphatase 2A (PP2A(T55)) composed of the catalytic (PP2Ac), structural (PR65/A), and regulatory (PR55/B) subunits was isolated from rabbit skeletal muscle by thiophosphorylase affinity chromatography, and contained two additional proteins of 54 and 55 kDa, respectively. The 54
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