SAB1306492
ANTI-ZO1(C-TERMINAL) antibody produced in rabbit
purified immunoglobulin, buffered aqueous solution
别名:
TJP1, Tight junction protein 1, Tight junction protein ZO-1, ZO1, Zona occludens protein 1
产品名称
ANTI-ZO1(C-TERMINAL) antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
195459 Da
species reactivity
human
technique(s)
flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TJP1(7082)
Application
ANTI-ZO1(C-TERMINAL) antibody produced in rabbit has been used in immunofluorescence.
Biochem/physiol Actions
Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) has a role in the formation of epithelial lumens. It interacts with occludin and modulates tight junction barrier regulation. ZO1 is also involved in the formation of the odontoblast layer and in actomyosin cytoskeleton regulation. Low expression of ZO1 has been linked to increased cell invasiveness in breast cancer, colorectal cancer and digestive tract cancers.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) is an adaptor protein. It acts as a scaffold protein between the tight junction and actin cytoskeleton. ZO1 has a molecular weight of 220kDa and is part of the membrane-associated guanylate kinase homolog family. The protein possesses three PDZ domains at its amino terminal, an SH3 domain and a region which bears homology to guanylate kinase. The ZO1 gene is localized on human chromosome 15q13.1.
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks.
Van Itallie CM, et al.
Journal de Biologie Buccale (2013)
Existence of Neural CresteDerived Progenitor
Cells in Normal and Fuchs Endothelial Dystrophy
Corneal Endothelium
Cells in Normal and Fuchs Endothelial Dystrophy
Corneal Endothelium
Kishore Reddy Katikireddy, et al.
The American Journal of Pathology (2016)
Increased ZO-1 expression predicts valuable prognosis in non-small cell lung cancer.
International Journal of Clinical and Experimental Pathology (2013)
ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
Tornavaca O, et al.
Journal of Cellular Biochemistry (2015)
Genome-wide association study of patient and clinician rated global impression severity during antipsychotic treatment
Shaunna L, et al.
Pharmacogenetics and Genomics (2013)
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