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生物来源
rabbit
质量水平
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
51896 Da
种属反应性
mouse, human
技术
flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... BECN1(8678)
相关类别
一般描述
Beclin 1 (BECN1) or GT197 is a tumor suppressor gene. It is a 450 amino-acid protein having three domains. The gene encoding BECN1 is localized on human chromosome 17q21.
应用
ANTI-BECLIN 1 antibody produced in rabbit has been used for Western blotting.
生化/生理作用
Beclin 1 (BECN1) or GT197 acts as an initiator of autophagy and is vital in the early stages of autophagosome formation. It has a role in various tumors and cancers. BECN1 is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking.
外形
Supplied in PBS with 0.09% (W/V) sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Polyglutamine tracts regulate beclin 1-dependent autophagy.
Ashkenazi A, et al.
Nature (2017)
The BECN1 N-terminal domain is intrinsically disordered.
Autophagy (2016)
Role of Autophagy in Breast Cancer
Vassiliki Karantza & Eileen White
Autophagy (2007)
Decreased expression of Beclin-1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma.
Hu Z, et al.
Molecular Medicine Reports (2016)
Class III phosphoinositide 3-kinase?Beclin1 complex mediates the amino
acid-dependent regulation of autophagy in C2C12 myotubes
acid-dependent regulation of autophagy in C2C12 myotubes
Amina TASSA, et al.
BioChemistry: An Indian Journal (2003)
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