推荐产品
生物来源
mouse
质量水平
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
137CT26.1.1, monoclonal
形式
buffered aqueous solution
分子量
41737 Da
种属反应性
mouse, human
技术
immunofluorescence: 1:10-1:50
immunohistochemistry: 1:25
western blot: 1:1000
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ACTB(60)
一般描述
β-actin (ACTB), a member of the actin multigene family, is an isoform of actin-associated with non-muscle cells. ACTB is a housekeeping gene mapped to human chromosome 7p22.1.
应用
Monoclonal Anti-Beta-Actin antibody produced in mouse has been used in western blotting at a dilution of 1:1000.
生化/生理作用
β-actin (ACTB) forms the core of the cell cytoskeleton. The polymerization of β-actin is essential for cell physiology. It may serve as a potential chemotherapeutic agent. Mutation in the ACTB gene is implicated in sensory hearing loss, delayed-onset generalized dystonia and a combination of ventral midline malformations. A loss-of-function mutation in the ACTB gene may cause intellectual disability.
外形
Supplied in PBS with 0.09% (W/V) sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Sara Cuvertino et al.
American journal of human genetics, 101(6), 1021-1033 (2017-12-09)
ACTB encodes β-actin, an abundant cytoskeletal housekeeping protein. In humans, postulated gain-of-function missense mutations cause Baraitser-Winter syndrome (BRWS), characterized by intellectual disability, cortical malformations, coloboma, sensorineural deafness, and typical facial features. To date, the consequences of loss-of-function ACTB mutations have
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Vincent Procaccio et al.
American journal of human genetics, 78(6), 947-960 (2006-05-11)
Actin, one of the major filamentous cytoskeletal molecules, is involved in a variety of cellular functions. Whereas an association between muscle actin mutations and skeletal and cardiac myopathies has been well documented, reports of human disease arising from mutations of
Sequence and structural analysis of beta-actin protein of fishes, using bioinformatics tools and techniques
Acharya UR, et al.
International journal of biosciences, 4(11) (2014)
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