SAB1305535
MONOCLONAL ANTI-MYC TAG antibody produced in mouse
clone 9E10, IgG fraction of antiserum, buffered aqueous solution
别名:
Tag from c-Myc protein
产品名称
MONOCLONAL ANTI-MYC TAG antibody produced in mouse, clone 9E10, IgG fraction of antiserum, buffered aqueous solution
biological source
mouse
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
9E10, monoclonal
form
buffered aqueous solution
technique(s)
western blot: 1:2,000
isotype
IgG1
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Application
MONOCLONAL ANTI-MYC TAG antibody produced in mouse has been used in Western blotting.
Biochem/physiol Actions
The cellular myelocytomatosis (c-myc) oncogene plays a vital role in cellular proliferation, differentiation, apoptosis and acts as transcriptional regulator of gene expression. c-myc expression is essential and sufficient to assist most of the cells to enter DNA synthetic (S) phase of the cell cycle. The encoded protein plays a crucial role in vasculogenesis and angiogenesis during cancer development and progression. c-myc interacts with its binding partner Max and activates the transcription of growth promoting genes such as cyclin D2 and ornithine decarboxylase. It also represses the transcription of multiple genes, especially p21 and p27, by binding to the transcription initiator element (Inr) in a complex with Max and either Sp1 or Miz1. Overexpression of MYC in DLBCL (diffuse large B-cell lymphoma) results in poor outcome and invasive treatment when medicated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
The cellular myelocytomatosis (c-myc) gene is mapped to human chromosome 8q24. It is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. c-myc is a member of MYC gene family.c-Myc gene codes for basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor that regulates the G1-S cell cycle transition.
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
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Smith DR, et al.
British Journal of Cancer, 68(2) (1993)
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PloS one, 7(5), e37111-e37111 (2012-05-17)
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Proceedings of the National Academy of Sciences of the United States of America, 115(19), E4522-E4531 (2018-04-25)
Abscisic acid (ABA) plays essential roles in plant development and responses to environmental stress. ABA induces subcellular translocation and degradation of the guanine nucleotide exchange factor RopGEF1, thus facilitating ABA core signal transduction. However, the underlying mechanisms for ABA-triggered RopGEF1
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.
Gordan JD,et al.
Cancer Cell, 11(4), 335-347 (2007)
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