生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
97402 Da
种属反应性
mouse
技术
western blot: 1:1000
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
mouse ... Nlrp6(101613)
一般描述
NLR家族含pyri结构域蛋白6（NLRP6）可能是炎症小体的一部分。它属于NOD样受体家族，在肠上皮细胞中表达。
生化/生理作用
NLR家族含pyri结构域蛋白6（NLRP6）在先天免疫中起作用。它也通过调节自噬和粘液分泌维持肠道稳态。已有研究证明NLRP6缺失可阻碍大鼠中白细胞介素-18（IL-18）的产生，并增进大鼠上皮诱导损伤的易感性。
外形
纯化多克隆抗体以PBS为溶剂，含有0.09% (W/V) 叠氮化钠。该抗体通过蛋白A柱以及随后的肽亲和纯化进行纯化。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
NLRP6 Protects Il10-/- Mice from Colitis by Limiting Colonization of Akkermansia muciniphila.
Seregin SS
Cellular Reprogramming (2017)
NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury.
Seregin SS
Mucosal Immunology (2017)
Pierre-Gregoire Coulon et al.
Frontiers in immunology, 10, 1631-1631 (2019-08-02)
The crosstalk between the host's inflammasome system and the invading virulent/less-virulent viruses determines the outcome of the ensuing inflammatory response. An appropriate activation of inflammasomes triggers antiviral inflammatory responses that clear the virus and heal the inflamed tissue. However, an
Qifeng Deng et al.
Redox biology, 49, 102217-102217 (2021-12-24)
Maintaining host iron homeostasis is an essential component of nutritional immunity responsible for sequestrating iron from pathogens and controlling infection. Nucleotide-oligomerization domain-like receptors (NLRs) contribute to cytoplasmic sensing and antimicrobial response orchestration. However, it remains unknown whether and how NLRs
Lanqing Sun et al.
Heliyon, 10(8), e28432-e28432 (2024-04-17)
Non-typhoidal Salmonella infection is among the most frequent foodborne diseases threatening human health worldwide. The host circadian clock orchestrates daily rhythms to adapt to environmental changes, including coordinating immune function in response to potential infections. However, the molecular mechanisms underlying
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