Anti-CLASP2 (N-term) antibody produced in rabbit

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

CLASP2 (NP_055912, )
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human CLASP2.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.