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Merck
CN
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安全信息

SAB1300754

Sigma-Aldrich

Anti-DDIT4 (C-term) antibody produced in rabbit

Ig fraction of antiserum, buffered aqueous solution

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别名:
Anti-HIF-1 responsive protein RTP801, Anti-Protein regulated in development and DNA damage response 1, Anti-REDD-1
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

Ig fraction of antiserum

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

种属反应性

human

技术

immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000

NCBI登记号

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... DDIT4(54541)

一般描述

REDD1 is a novel transcriptional target of p53 induced following DNA damage. During embryogenesis, REDD1 expression mirrors the tissue-specific pattern of the p53 family member p63, and TP63 null embryos show virtually no expression of REDD1, which is restored in mouse embryo fibroblasts following p63 expression. In differentiating primary keratinocytes, TP63 and REDD1 expression are coordinately downregulated, and ectopic expression of either gene inhibits in vitro differentiation. REDD1 appears to function in the regulation of reactive oxygen species (ROS); TP63 null fibroblasts have decreased ROS levels and reduced sensitivity to oxidative stress, which are both increased following ectopic expression of either TP63 or REDD1. Thus, REDD1 encodes a shared transcriptional target that implicates ROS in the p53-dependent DNA damage response and in p63-mediated regulation of epithelial differentiation.

免疫原

DDIT4 (NP_061931, 203-237)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DDIT4.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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