SAB1100901
Anti-ARPC4 (26-40) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-ARC20, Anti-Actin related protein 2/3 complex, subunit 4, Anti-p20-Arc
产品名称
Anti-ARPC4 (26-40) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~20 kDa
species reactivity
human
technique(s)
indirect immunofluorescence: suitable
western blot: 1:500-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ARPC4(10093)
Application
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Biochem/physiol Actions
Actin related protein 2/3 complex, subunit 4 (ARPC4) in plants is crucial for action dynamics and cordinates the tip growth and movement. It is highly expressed in most of the pancreatic carcinoma and may regulate cancer cell migration. It interacts with mycobacterial protein Rv1626 and its expression in Mycobacterium tuberculosis impacts its survival and infection profile, making it an effective anti-tuberculosis drug candidate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Actin related protein 2/3 complex, subunit 4 (ARPC4) is mapped to human chromosome 3p25.3. It is part of the ARP2/3 complex which connects this complex to the mother filament.
Immunogen
synthetic peptide corresponding to amino acids 26-40 of human ARPC4
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Expression of the ARPC4 subunit of human Arp2/3 severely affects Mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages
Ghosh A, et al.
Testing, 8(7), e69949-e69949 (2013)
The role of ARPC4 in tip growth and alignment of the polar axis in filaments of Physcomitrella patens
Perroud PF and Quatrano RS
Cell Motility and the Cytoskeleton, 63(3), 162-171 (2006)
3p- syndrome defines a hearing loss locus in 3p25.3
McCullough BJ, et al.
Hearing Research, 224(1-2), 51-60 (2007)
Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration
Rauhala HE, et al.
Anticancer Research, 33(1), 45-52 (2013)
Chiara Galloni et al.
The Journal of cell biology, 220(8) (2021-06-10)
The mechanisms regulating the disassembly of branched actin networks formed by the Arp2/3 complex still remain to be fully elucidated. In addition, the impact of Arp3 isoforms on the properties of Arp2/3 are also unexplored. We now demonstrate that Arp3
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