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安全信息

S9820

Sigma-Aldrich

SU 11274

≥98% (HPLC), powder

别名:

(3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide

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About This Item

经验公式（希尔记法）:
C28H30ClN5O4S
CAS号:
658084-23-2
分子量:
568.09
MDL编号:
MFCD08276928
UNSPSC代码:
12352200
PubChem化学物质编号:
24724625
NACRES:
NA.77

方案

≥98% (HPLC)

表单

powder

颜色

orange

溶解性

DMSO: 10 mg/mL at 60 °C
H2O: insoluble

储存温度

2-8°C

SMILES字符串

CN1CCN(CC1)C(=O)c2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(cc34)S(=O)(=O)N(C)c5cccc(Cl)c5)c2C

InChI

1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-

InChI key

FPYJSJDOHRDAMT-KQWNVCNZSA-N

应用

SU 11274 was used to inhibit c-Met in non-small cell lung cancer cell lines.3
SU11274 has been used:
  • To study the role of hepatocyte growth factor (HGF) in human vestibular schwannoma proliferation.
  • To study its effect on human gastric carcinoma cell line MKN-45.
  • To study the effect of HGF on phosphorylation of epidermal growth factor receptor, c-Met and other signaling pathways.

生化/生理作用

SU 11274 is a Met tyrosine kinase inhibitor.
SU 11274 is a class I c-Met inhibitor that competes with ATP to bind to the activation loop of c-Met.1 Inhibition of c-Met by SU 11274 is effective in improving the clinical outcome in non-small cell lung cancer cell lines.2
c-Met kinase is a hepatocyte growth factor, involved in tumor invasion process and thus it serves as therapeutic target for cancer. It is found that SU11274 showed decreased tumor progression in human melanoma, by reducing tumor growth and metastasis.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000004020
0000004021
0000002138
072M4606V
050M46041V

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Gang Chen et al.
PloS one, 8(3), e59708-e59708 (2013-03-26)
Epidermal growth factor receptor (EGFR) and c-MET receptors are expressed on many non-small cell lung cancer (NSCLC) cells. Current single agent therapeutic targeting of a mutant EGFR has a high efficacy in the clinic, but is not curative. Here, we
Mechanism of resistance and novel targets mediating resistance to EGFR and c-Met tyrosine kinase inhibitors in non-small cell lung cancer
Botting GM, et al.
Testing, 10(8), e0136155-e0136155 (2015)
Anum Mughal et al.
Infectious agents and cancer, 8(1), 13-13 (2013-04-10)
c-Met is a receptor tyrosine kinase that encodes protein such as hepatocyte growth factor receptor (HGFR). Inappropriate activity of c-Met can cause wide variety of carcinomas. c-Met inhibitor are relatively new class of small molecules that inhibit the enzymatic activity
Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation (2013)
Complementary PTM profiling of drug response in human gastric carcinoma by immunoaffinity and IMAC methods with total proteome analysis
Stokes MP, et al.
Proteome, 3(3), 160-183 (2015)
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