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方案
≥98% (HPLC)
质量水平
表单
powder
旋光性
[α]/D ≥+225°, c = 1 in H2O
颜色
white to tan
溶解性
H2O: ≥18 mg/mL
储存温度
2-8°C
SMILES字符串
CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O
InChI
1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1
InChI key
FKENQMMABCRJMK-RITPCOANSA-N
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一般描述
舒巴坦是一种半合成青霉素砜，来源于6-氨基青霉烷酸。这种β-内酰胺化合物的特征为具有一个 β-内酰胺环。
应用
舒巴坦可用作β-内酰胺酶抑制剂测试中的β-内酰胺酶抑制剂。 它也可用于评估其对极端耐药的鲍曼不动杆菌的抗菌药效学作用。舒巴坦可用于细胞信号转导研究。
生化/生理作用
舒巴坦为 β-内酰胺酶的不可逆抑制剂，可使β-内酰胺如青霉素和头孢菌素失活。它也可对拟杆菌和革兰氏阴性菌的某些染色体介导酶起作用。它具有有限的抗菌活性。 但是，舒巴坦与其它潜在抗生素的联合使用对多重耐药型鲍曼不动杆菌感染有治疗作用。
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sarah M Drawz et al.
Clinical microbiology reviews, 23(1), 160-201 (2010-01-13)
Since the introduction of penicillin, beta-lactam antibiotics have been the antimicrobial agents of choice. Unfortunately, the efficacy of these life-saving antibiotics is significantly threatened by bacterial beta-lactamases. beta-Lactamases are now responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems.
Mallika Sengupta et al.
Cureus, 14(2), e21802-e21802 (2022-03-08)
Background Acinetobacter species are known to be important hospital-acquired pathogens. Unfortunately, multidrug-resistant Acinetobacter spp. has very limited options for an effective treatment. Aim To identify the common pathogens causing lower respiratory tract infections (LRTI), their antimicrobial susceptibility pattern, and determine the minimum inhibitory
Krisztina M Papp-Wallace et al.
Antimicrobial agents and chemotherapy, 56(11), 5687-5692 (2012-08-22)
Acinetobacter baumannii is an increasingly problematic pathogen in United States hospitals. Antibiotics that can treat A. baumannii are becoming more limited. Little is known about the contributions of penicillin binding proteins (PBPs), the target of β-lactam antibiotics, to β-lactam-sulbactam susceptibility
Robert K Flamm et al.
Antimicrobial agents and chemotherapy, 59(4), 2280-2285 (2015-02-04)
RX-P873 is a novel antibiotic from the pyrrolocytosine series which exhibits high binding affinity for the bacterial ribosome and broad-spectrum antibiotic properties. The pyrrolocytosines have shown in vitro activity against multidrug-resistant Gram-negative and Gram-positive strains of bacteria known to cause
M Akova
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 14 Suppl 1, 185-188 (2007-12-25)
Sulbactam irreversibly inhibits the hydrolytic activity of beta-lactamases. This compound is commercially available in combination with either ampicillin or cefoperazone. In each instance, the activity of the partner antibiotic against beta-lactamase-producing bacteria is restored. One of the particular advantages of
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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