所有图片(1)
About This Item
经验公式（希尔记法）:
C18H19NO3S2
CAS号:
分子量:
361.48
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
lyophilized powder
颜色
white
溶解性
DMSO: ≥30 mg/mL
储存温度
2-8°C
SMILES字符串
CCOC(=O)C1Cc2ccccc2CN1C(=O)c3ccc(SC)s3
InChI
1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3
InChI key
UIEBLUZPSFAFOC-UHFFFAOYSA-N
应用
SR8278可用作rev-erbα拮抗剂，研究胰高血糖素分泌对小鼠胰岛α细胞和β细胞的调节作用。
SR8278已被用作核受体亚家族1D组成员1（NR1D1）拮抗剂，以研究其对饥饿诱导的巨噬细胞的作用。
生化/生理作用
SR8278是核血红素受体REV-ERB拮抗剂。
SR8278是核血红素受体REV-ERB拮抗剂。REV-ERBα通过抑制靶基因活性在调节昼夜节律中起关键作用。另外，研究表明，REV-ERBα可调节脂质和葡萄糖代谢等代谢过程。 SR8278可阻断合成激动剂GSK4112增强REV-ERBα依赖性抑制的能力、刺激参与糖异生的REV-ERBα靶基因的表达。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy
Chandra V, et al.
Autophagy, 11(11), 1987-1997 (2015)
Dapeng Yu et al.
International immunopharmacology, 73, 312-320 (2019-05-28)
Progressive lung injury and pulmonary inflammation can be induced by an intraperitoneal injection of lipopolysaccharide (LPS). Interleukin-1β (IL-1β) is a key pro-inflammatory cytokine that can further exaggerate inflammation, which is cleaved and activated by the NALP3 inflammasome. Although the nuclear
Lianxia Guo et al.
British journal of pharmacology, 178(2), 328-345 (2020-10-18)
Acute kidney injury (AKI) is a common and critical illness, resulting in severe morbidity and a high mortality. There is a considerable interest in identifying novel molecular targets for management of AKI. We investigated the potential role of the circadian
Elaine Vieira et al.
Endocrinology, 153(2), 592-601 (2011-12-15)
Disturbances of circadian rhythms have been associated with obesity and type 2 diabetes. The nuclear receptor Rev-erbα was suggested to link circadian rhythms and metabolism in peripheral tissues. The aim of the present study was to dissect the role of
Elaine Vieira et al.
PloS one, 8(7), e69939-e69939 (2013-08-13)
Disruption of pancreatic clock genes impairs pancreatic beta-cell function, leading to the onset of diabetes. Despite the importance of pancreatic alpha-cells in the regulation of glucose homeostasis and in diabetes pathophysiology, nothing is known about the role of clock genes
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