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S9318

Sigma-Aldrich

Sandoz 58-035

>98% (HPLC), powder, acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor

别名:

3-[癸基二甲基甲硅烷基] -N- [2-（4-甲基苯基）-1-苯乙基]丙酰胺, SA 58-035

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About This Item

经验公式（希尔记法）:
C30H47NOSi
CAS号:
78934-83-5
分子量:
465.79
MDL编号:
MFCD00161339
UNSPSC代码:
41121801
PubChem化学物质编号:
24278227
NACRES:
NA.77

产品名称

Sandoz 58-035, >98% (HPLC), powder

质量水平

100

方案

>98% (HPLC)

表单

powder

颜色

white

溶解性

DMSO: 16 mg/mL
H2O: insoluble

创始人

Novartis

储存温度

2-8°C

SMILES字符串

CCCCCCCCCC[Si](C)(C)CCC(=O)NC(Cc1ccc(C)cc1)c2ccccc2

InChI

1S/C30H47NOSi/c1-5-6-7-8-9-10-11-15-23-33(3,4)24-22-30(32)31-29(28-16-13-12-14-17-28)25-27-20-18-26(2)19-21-27/h12-14,16-21,29H,5-11,15,22-25H2,1-4H3,(H,31,32)

InChI key

NBYATBIMYLFITE-UHFFFAOYSA-N

基因信息

human ... SOAT1(6646)
rat ... Soat1(81782)

应用

Sandoz 58-035 用于诱导小鼠腹腔巨噬细胞中未折叠蛋白反应（UPR）和模式识别受体（PRR）的同时激活。3

生化/生理作用

Sandoz 58-035 抑制胆固醇酯的积累，抑制培养物中动脉平滑肌细胞 95％ 的胆固醇酯化。1它不影响肠道甘油三酯代谢。2
酰基辅酶 A：胆固醇酰基转移酶（ACAT）抑制剂。

特点和优势

该化合物由 Novartis 开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000283252
0000283252
0000179274
0000179274
0000134126

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Julia T Stadler et al.
Biomedicines, 9(3) (2021-03-07)
Obesity increases the risk of coronary heart disease, partly due to its strong association with atherogenic dyslipidemia, characterized by high triglycerides and low high-density lipoprotein (HDL) cholesterol levels. Functional impairment of HDL may contribute to the increased cardiovascular mortality, but
Masato Furuhashi et al.
Scientific reports, 7(1), 217-217 (2017-03-18)
Cholesterol efflux capacity (CEC) from macrophages, the first step in the reverse cholesterol transport pathway, is inversely associated with residual risk for atherosclerotic cardiovascular disease. Fatty acid-binding protein 4 (FABP4) and FABP5 are expressed in both adipocytes and macrophages and
Irene Schilcher et al.
Scientific reports, 7(1), 12485-12485 (2017-10-04)
Endothelial lipase (EL) is a potent modulator of the structural and functional properties of HDL. Impact of EL on cholesterol efflux capacity (CEC) of serum and isolated HDL is not well understood and apparently contradictory data were published. Here, we
Markus Trieb et al.
Journal of hepatology, 73(1), 113-120 (2020-02-18)
High-density lipoprotein cholesterol (HDL-C) levels are reduced in patients with chronic liver disease and inversely correlate with disease severity. During acute conditions such as sepsis, HDL-C levels decrease rapidly and HDL particles undergo profound changes in their composition and function.
Shelley J Edmunds et al.
Scientific reports, 10(1), 18070-18070 (2020-10-24)
Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) induces glucose uptake by muscle tissues and stimulates pancreatic insulin secretion, and also facilitates cholesterol transport in circulation, and is explored for anti-diabetic and anti-atherosclerotic treatments. As the better alternative to complex protein-lipid
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