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Merck
CN

S9318

Sandoz 58-035

>98% (HPLC), powder, acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor

别名:

3-[癸基二甲基甲硅烷基] -N- [2-（4-甲基苯基）-1-苯乙基]丙酰胺, SA 58-035

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关于此项目

经验公式（希尔记法）:
C30H47NOSi
化学文摘社编号:
78934-83-5
分子量:
465.79
UNSPSC Code:
41121801
PubChem Substance ID:
24278227
NACRES:
NA.77
MDL number:
MFCD00161339
Assay:
>98% (HPLC)
Form:
powder
Quality level:
100

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产品名称

Sandoz 58-035, >98% (HPLC), powder

SMILES string

CCCCCCCCCC[Si](C)(C)CCC(=O)NC(Cc1ccc(C)cc1)c2ccccc2

InChI key

NBYATBIMYLFITE-UHFFFAOYSA-N

InChI

1S/C30H47NOSi/c1-5-6-7-8-9-10-11-15-23-33(3,4)24-22-30(32)31-29(28-16-13-12-14-17-28)25-27-20-18-26(2)19-21-27/h12-14,16-21,29H,5-11,15,22-25H2,1-4H3,(H,31,32)

assay

>98% (HPLC)

form

powder

color

white

solubility

DMSO: 16 mg/mL
H2O: insoluble

originator

Novartis

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... SOAT1(6646)
rat ... Soat1(81782)

相关类别

Application

Sandoz 58-035 用于诱导小鼠腹腔巨噬细胞中未折叠蛋白反应（UPR）和模式识别受体（PRR）的同时激活。3

Biochem/physiol Actions

Sandoz 58-035 抑制胆固醇酯的积累，抑制培养物中动脉平滑肌细胞 95％ 的胆固醇酯化。1它不影响肠道甘油三酯代谢。2
酰基辅酶 A：胆固醇酰基转移酶（ACAT）抑制剂。

Features and Benefits

该化合物由 Novartis 开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000500033
0000500032
0000500032
0000500033
0000440528

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Shelley J Edmunds et al.
Scientific reports, 10(1), 18070-18070 (2020-10-24)
Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) induces glucose uptake by muscle tissues and stimulates pancreatic insulin secretion, and also facilitates cholesterol transport in circulation, and is explored for anti-diabetic and anti-atherosclerotic treatments. As the better alternative to complex protein-lipid
H Hakamata et al.
Arteriosclerosis and thrombosis : a journal of vascular biology, 14(11), 1860-1865 (1994-11-01)
The species difference in the turnover rates of the cholesteryl ester (CE) cycle in macrophage foam cells (MFC) was examined in mice and rats. MFC were induced by acetyl-LDL and pulsed with [3H]oleate, followed by a chase with [14C]oleate. The
Shizuya Yamashita et al.
Journal of clinical lipidology, 12(5), 1267-1279 (2018-08-06)
Cardiovascular risk is negatively correlated with cholesterol efflux capacity (CEC) from macrophages to high-density lipoproteins (HDLs) and positively correlated with fasting and nonfasting triglyceride-rich lipoproteins (TRLs). Pemafibrate, a novel selective peroxisome proliferator-activated receptor α modulator, robustly decreases the fasting TRL
Hiroshi Hirata et al.
The Journal of nutritional biochemistry, 47, 29-34 (2017-05-16)
Xanthohumol, a prominent prenyl flavonoid from the hop plant (Humulus lupulus L.), is suggested to be antiatherogenic since it reportedly increases high-density lipoprotein (HDL) cholesterol levels. It is not clear whether xanthohumol promotes reverse cholesterol transport (RCT), the most important
K Cianflone et al.
Atherosclerosis, 107(2), 125-135 (1994-06-01)
This study examines the effects of extracellular albumin on hepatic apo B-100 metabolism. To do so, a transformed human liver cell line, HepG2, was used as a hepatocyte model and the concentration of albumin in the medium was varied between
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胆固醇酯化TEST

胆固醇酯化可改善运输。胆固醇酯可更轻松地封装在脂蛋白内部-增加了在血液中可轻松运输的胆固醇数量。

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