InChI key
PEYUIKBAABKQKQ-AFHBHXEDSA-N
SMILES string
C1Oc2ccc(cc2O1)[C@H]3OC[C@H]4[C@@H]3CO[C@@H]4c5ccc6OCOc6c5
InChI
1S/C20H18O6/c1-3-15-17(25-9-23-15)5-11(1)19-13-7-22-20(14(13)8-21-19)12-2-4-16-18(6-12)26-10-24-16/h1-6,13-14,19-20H,7-10H2/t13-,14-,19+,20+/m0/s1
biological source
Sesamum indicum (sesame)
assay
≥95%
form
crystalline
shipped in
wet ice
storage temp.
−20°C
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General description
芝麻素是存在于芝麻种子中的脂溶性呋喃木酚素。
Application
芝麻素已被用于：
- 作为木酚素用于研究其对大鼠骨髓基质细胞（BMSC）成骨细胞分化的影响
- 作为分离芝麻油中芝麻素的标准品
- 研究其作为内源性木酚素（enterolignan）对雌激素受体（ER）阳性人乳腺癌MCF-7细胞增殖的影响
Biochem/physiol Actions
芝麻素可以降低人体内胆固醇的作用。它参与预防高血压，并增加维生素E水平。芝麻素具有抗癌、抗增殖、抗转移和抗炎特性。它还具有促凋亡和促自噬特性。芝麻素对脂质和碳水化合物的代谢有影响。它还对高血压和自由基清除有影响。
非竞争性δ 5-去饱和酶抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
N Hirose et al.
Journal of lipid research, 32(4), 629-638 (1991-04-01)
The effects of sesamin, a lignan from sesame oil, on various aspects of cholesterol metabolism were examined in rats maintained on various dietary regimens. When given at a dietary level of 0.5% for 4 weeks, sesamin reduced the concentration of
Amin F Majdalawieh et al.
European journal of pharmacology, 815, 512-521 (2017-10-17)
Sesamin is the major active ingredient is Sesamum indicum seeds. Several studies revealed that sesamin possesses potent anti-cancer properties. The anti-cancer effects of sesamin have been mainly attributed to its anti-proliferative, pro-apoptotic, anti-inflammatory, anti-metastatic, anti- and pro-angiogenic, and pro-autophagocytic activities.
Zhong-Ping Ma et al.
Medical science monitor : international medical journal of experimental and clinical research, 25, 5312-5320 (2019-07-18)
BACKGROUND Osteoporosis is a common osteopathy, resulting in fractures, especially in elder people. Sesamin has many pharmacological effects, including supplying calcium. However, how sesamin might prevent osteoporosis is still under study. MATERIAL AND METHODS Bone marrow stromal cells (BMSCs) extracted
Value addition in sesame: A perspective on bioactive components for enhancing utility and profitability
Pathak N, et al.
Pharmacognosy reviews, 8(16), 147-147 (2014)
Jean Fotie et al.
Journal of natural products, 70(10), 1650-1653 (2007-09-21)
Three benzo[ c]phenanthridine alkaloids have been isolated from the stem bark of Garcinia lucida: dihydrochelerythrine ( 1), 6-acetonyldihydrochelerythrine ( 2), and its new derivative, ( S)1''-(9,10-dihydro-2',3'-dihydroxy-7,8-dimethoxy-10-methyl-1,2-benzophenanthridin-9-yl)propan-2''-one (lucidamine A) ( 3). The new diisoprenylated derivative of lucidamine B ( 4) was
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