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安全信息

S9132

Sigma-Aldrich

螺旋霉素

别名:

Rovamycin, Formacidine

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About This Item

CAS号:
8025-81-8
EC 号:
232-429-6
MDL编号:
MFCD01314545
UNSPSC代码:
51283208
PubChem化学物质编号:
24899826
NACRES:
NA.85

表单

powder

质量水平

200

旋光性

[α]/D -85 to -80° in water (Specific rotation (dry basis))

效能

≥4100 I.U. per mg (dry basis)

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

颜色

white to light yellow

溶解性

methanol: soluble

痕量阳离子

heavy metals: ≤20 ppm

抗生素抗菌谱

Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](OC2CCC(C(C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1OC3OC(C)C(OC4CC(C)(O)C(O)C(C)O4)C(C3O)N(C)C

InChI

1S/C43H74N2O14/c1-24-21-29(19-20-46)39(59-42-37(49)36(45(9)10)38(27(4)56-42)58-35-23-43(6,51)41(50)28(5)55-35)40(52-11)31(47)22-33(48)53-25(2)15-13-12-14-16-32(24)57-34-18-17-30(44(7)8)26(3)54-34/h12-14,16,20,24-32,34-42,47,49-51H,15,17-19,21-23H2,1-11H3/b13-12+,16-14+/t24-,25-,26?,27?,28?,29+,30?,31-,32+,34?,35?,36?,37?,38?,39+,40+,41?,42?,43?/m1/s1

InChI key

ACTOXUHEUCPTEW-JMRHEKERSA-N

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相关类别

一般描述

Chemical structure: macrolide

应用

Spiramycin is a macrolide antibiotic that is commonly used to treat infections of soft tissues. It has been used to treat bronchopulmonary infections in adults and has been used to study septicemia in mice .

生化/生理作用

Spiramycin is a 16-membered ring macrolide antibiotic from Streptomyces ambofaciens. It inhibits bacterial protein synthesis at the level of peptidy-tRNA dissociation from ribosomes. It is mainly used against Gram-positive bacteria.

质量

A mixture of Spiramycin I, II and III.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
MKCV6785
MKCW9212
MKCS9688
MKCQ3681
MKCN6048

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O Rolin et al.
Pathologie-biologie, 34(5), 476-478 (1986-05-01)
Experimental septicemia was induced in mice by intraperitoneal injection of 10 to 100 lethal doses of Staphylococcus aureus and Streptococcus pneumoniae. Animals were treated by a mixture of adipic acid and spiramycin (subcutaneous route) or by spiramycin base (oral route)
Acute bronchopulmonary infections: treatment with i.v. spiramycin.
F Vachon and S Kernbaum
Chemotherapia, 6, 282-285 (1987)
I Brook
Clinical pharmacokinetics, 34(4), 303-310 (1998-05-08)
The absolute bioavailability of oral spiramycin is generally within the range of 30 to 40%. After a 1 g oral dose, the maximum serum drug concentration was found to be within the range 0.4 to 1.4 mg/L. The tissue distribution
Severe congenital toxoplasmosis due to a Toxoplasma gondii strain with an atypical genotype: case report and review.
Laurence Delhaes et al.
Prenatal diagnosis, 30(9), 902-905 (2010-06-29)
Ming-juan Wang et al.
Journal of chromatography. A, 1217(42), 6531-6544 (2010-09-17)
Investigation of acetylspiramycin (ASPM) and its related substances was carried out using a reversed-phase liquid chromatography/tandem mass spectrometry method. The identification of impurities in the ASPM complex was performed with a quadrupole ion trap mass spectrometer, with an electrospray ionization
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