S9007

壮观霉素二盐酸盐五水合物

Name: 壮观霉素 二盐酸盐 五水合物
Brand: SIGMA

potency: ≥603 μg per mg

别名:

Actinospectacin, Actinospectacin dihydrochloride pentahydrate, Spectinomycin, Spectinomycin HCL, Spectinomycin Hydrochloride, Spectinomycin hydrochloride

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关于此项目

经验公式（希尔记法）:

C₁₄H₂₄N₂O₇ · 2HCl · 5H₂O

化学文摘社编号:

22189-32-8

分子量:

495.35

NACRES:

NA.85

PubChem Substance ID:

24899822

UNSPSC Code:

51281666

EC Number:

244-554-3

MDL number:

MFCD00150886

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产品名称

壮观霉素二盐酸盐五水合物, potency: ≥603 μg per mg

InChI key

DCHJOVNPPSBWHK-UXXUFHFZSA-N

InChI

1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1

SMILES string

O.O.O.O.O.Cl.Cl.CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O

biological source

synthetic (inorganic)

form

powder

potency

≥603 μg per mg

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

color

white to pale buff

solubility

H₂O: soluble 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

application(s)

agriculture

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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Application

大观霉素是一种氨基环糖醇类抗生素，来源于 壮观链霉菌。它已被证明具有广泛的用途，包括治疗急性淋病性尿道炎和宫颈炎、标记细胞层以监测叶片发育期间的细胞命运、作为含有标记基因 Spcr 的植物相关转化系统中的选择标记、研究由 多杀性巴氏杆菌 和 溶血性曼氏杆菌 引起的牛呼吸道感染以及在 MS 琼脂培养基上产生质体编码 RNA 聚合酶缺乏的植物。大观霉素也可用于扩增携带低拷贝数的质粒。推荐在 7.5-20 mg/L 下用于细胞培养应用。

Biochem/physiol Actions

作用机制：壮观霉素通过与细菌30S核糖体亚基结合并干扰肽基tRNA易位而抑制蛋白质合成和延伸。

抗性机制：rpsE（核糖体蛋白S5的基因）突变可阻止壮观霉素的结合。氨基糖苷-3′-腺苷转移酶基因（aadA）也能使细菌产生抗性。

抗菌谱：壮观霉素能够对抗革兰氏阴性和革兰氏阳性菌。

Disclaimer

溶液可以在2-8°C下储存数周，或在-20°C下储存更长时间。

General description

化学结构：氨基糖苷类

Other Notes

保存于密闭容器内，置于干燥通风处。

Preparation Note

制备储液时，应以10 mg/mL溶于水并过滤灭菌。

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000519653

0000470455

0000442958

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Unexpected Diversity of Chloroplast Noncoding RNAs as Revealed by Deep Sequencing of the Arabidopsis Transcriptome.

Amber M Hotto et al.

G3 (Bethesda, Md.), 1(7), 559-570 (2012-03-03)

Noncoding RNAs (ncRNA) are widely expressed in both prokaryotes and eukaryotes. Eukaryotic ncRNAs are commonly micro- and small-interfering RNAs (18-25 nt) involved in posttranscriptional gene silencing, whereas prokaryotic ncRNAs vary in size and are involved in various aspects of gene

In vitro activities of spectinomycin and comparator agents against Pasteurella multocida and Mannheimia haemolytica from respiratory tract infections of cattle.

Stefan Schwarz et al.

The Journal of antimicrobial chemotherapy, 53(2), 379-382 (2004-01-20)

Prior to the renewal of spectinomycin licensing for veterinary uses in Germany, 154 Pasteurella multocida and 148 Mannheimia haemolytica strains from respiratory tract infections in cattle were investigated for their MICs of spectinomycin and other antimicrobial agents. The data obtained

A real-time PCR antibiogram for drug-resistant sepsis.

John R Waldeisen et al.

PloS one, 6(12), e28528-e28528 (2011-12-14)

Current molecular diagnostic techniques for susceptibility testing of septicemia rely on genotyping for the presence of known resistance cassettes. This technique is intrinsically vulnerable due to the inability to detect newly emergent resistance genes. Traditional phenotypic susceptibility testing has always

Novel shuttle markers for nuclear transformation of the green alga Chlamydomonas reinhardtii.

Laurence Meslet-Cladière et al.

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The green alga Chlamydomonas reinhardtii today is a premier model organism for the study of green algae and plants. Yet the efficient engineering of its nuclear genome requires development of new antibiotic resistance markers. We have recoded, based on codon

Neisseria gonorrhoeae strain with high-level resistance to spectinomycin due to a novel resistance mechanism (mutated ribosomal protein S5) verified in Norway.

Magnus Unemo et al.

Antimicrobial agents and chemotherapy, 57(2), 1057-1061 (2012-11-28)

Gonorrhea may become untreatable, and new treatment options are essential. Verified resistance to spectinomycin is exceedingly rare. However, we describe a high-level spectinomycin-resistant (MIC, >1,024 μg/ml) Neisseria gonorrhoeae strain from Norway with a novel resistance mechanism. The resistance determinant was

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壮观霉素 二盐酸盐 五水合物

potency: ≥603 μg per mg

选择尺寸

关于此项目

主要文件

属性

产品名称

InChI key

InChI

SMILES string

biological source

form

potency

storage condition

color

solubility

antibiotic activity spectrum

application(s)

mode of action

storage temp.

Quality Level

相关类别

说明

Application

Biochem/physiol Actions

Disclaimer

General description

Other Notes

Preparation Note

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

存储类别

wgk

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

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壮观霉素二盐酸盐五水合物