重组
expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged)
质量水平
表单
buffered aqueous solution
分子量
~48 kDa by SDS-PAGE
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... SGK1(6446)
一般描述
The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23.
生化/生理作用
Kinase assays.
The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.
单位定义
One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.
外形
Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.
法律信息
Brij is a registered trademark of Croda International PLC
储存分类代码
10 - Combustible liquids
法规信息
新产品
SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition.
Talarico C
Cellular Physiology and Biochemistry (2016)
mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation
Feng Hong
Molecular Cell, 30(6) (2011)
Serum glucocorticoid inducible kinase (SGK)-1 protects endothelial cells against oxidative stress and apoptosis induced by hyperglycaemia.
Ferrelli F
Acta Diabetologica (2015)
Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables
David W Ellison
Journal of Clinical Oncology (2011)
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