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Merck
CN

S8826

Sigma-Aldrich

塞马克斯

≥98% (HPLC)

别名:

ACTH (4-7) ,脯氨酸-甘氨酸-脯氨酸 三氟乙酸盐, L-甲硫氨酰-L-a-谷氨酰-L-组氨酰-L-苯丙氨酰-L-脯氨酰甘氨酰-L-脯氨酸 三氟乙酸盐, Met-Glu-His-Phe-Pro-Gly-Pro

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About This Item

经验公式(希尔记法):
C37H51N9O10S · xC2HF3O2
CAS号:
分子量:
813.92 (free base basis)
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.32

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to tan

溶解性

H2O: >2 mg/mL

运输

wet ice

储存温度

−20°C

SMILES字符串

OC(=O)C(F)(F)F.CSCC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N3CCC[C@H]3C(=O)NCC(=O)N4CCC[C@H]4C(O)=O

InChI

1S/C37H51N9O10S.C2HF3O2/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56;3-2(4,5)1(6)7/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56);(H,6,7)/t24-,25-,26-,27-,28-,29-;/m0./s1

InChI key

UAXRUQRHZBYPHF-IGCYJKAMSA-N

一般描述

Semax 调节海马(脑源性神经营养因子)BDNF/(原肌球蛋白受体激酶 B)trkB 系统的表达和激活。它增强信息接收时的选择性注意,增强记忆巩固和刺激学习能力。Semax 是 Semax 药物的活性成分,用于治疗脑缺氧和缺血。它刺激胆碱乙酰转移酶的活性。Semax 具有黑皮质素 (MC) 受体拮抗剂的属性。

生化/生理作用

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) 是促肾上腺皮质激素片段的类似物 (4-10)。它激活神经营养因子的转录,具有神经保护和促智活性。
Semax 是一种神经保护 ACTH (4-10) 类似物。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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M E Grigorjeva et al.
Bulletin of experimental biology and medicine, 149(1), 44-46 (2010-11-30)
The effects of semax on anticoagulant, fibrinolytic, and platelet components of the anticoagulation system were studied on albino rats under conditions of acute and chronic immobilization stress. Semax exhibited a protective antistress effect after repeated intranasal administration under conditions of
M A Volodina et al.
Bulletin of experimental biology and medicine, 152(5), 560-563 (2012-07-18)
Maternal deprivation in the early postnatal period significantly affects the behavior and development of different animals. Here we studied delayed effects of daily maternal deprivation (5 h/day) on physical development and behavior of white rats during postnatal days 1 to
A A Bakhmet et al.
Bulletin of experimental biology and medicine, 153(5), 661-663 (2012-11-01)
We studied the effect of antistress peptide Semax, an ACTH4-10 analogue, on the cellular composition of spleen lymphoid structures in Wistar rats with different stress tolerance in the course of post-stress recovery (days 1, 3, 14, and 30). Preliminary administration
Ekaterina V Medvedeva et al.
Journal of molecular neuroscience : MN, 49(2), 328-333 (2012-07-10)
The synthetic peptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is used successfully in acute stroke therapy. In spite of numerous studies on the subject, many aspects of the neuroprotective effects of the peptide remain unknown. We studied the action of Semax and its C-terminal
K V Shevchenko et al.
Bioorganicheskaia khimiia, 37(4), 475-482 (2011-11-22)
Proteolysis of semax (Met-Glu-His-Phe-Pro-Gly-Pro, Sem) and its analogues ([Ala1]Sem, [Gly1]Sem, [Thr1]Sem, [Trp1]Sem) that are differ from semax in substitution of N-terminal Met residue were studied. It is shown that such replacement changes the rate of peptides degradation by N-aminopeptidases (EC

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