质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to tan
溶解性
H2O: >2 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
OC(=O)C(F)(F)F.CSCC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N3CCC[C@H]3C(=O)NCC(=O)N4CCC[C@H]4C(O)=O
InChI
1S/C37H51N9O10S.C2HF3O2/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56;3-2(4,5)1(6)7/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56);(H,6,7)/t24-,25-,26-,27-,28-,29-;/m0./s1
InChI key
UAXRUQRHZBYPHF-IGCYJKAMSA-N
一般描述
Semax 调节海马（脑源性神经营养因子）BDNF/（原肌球蛋白受体激酶 B）trkB 系统的表达和激活。它增强信息接收时的选择性注意，增强记忆巩固和刺激学习能力。Semax 是 Semax 药物的活性成分，用于治疗脑缺氧和缺血。它刺激胆碱乙酰转移酶的活性。Semax 具有黑皮质素 (MC) 受体拮抗剂的属性。
生化/生理作用
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) 是促肾上腺皮质激素片段的类似物 (4-10)。它激活神经营养因子的转录，具有神经保护和促智活性。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
M E Grigorjeva et al.
Bulletin of experimental biology and medicine, 149(1), 44-46 (2010-11-30)
The effects of semax on anticoagulant, fibrinolytic, and platelet components of the anticoagulation system were studied on albino rats under conditions of acute and chronic immobilization stress. Semax exhibited a protective antistress effect after repeated intranasal administration under conditions of
D M Manchenko et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 96(10), 1014-1023 (2011-01-29)
Heptapeptide Semax (MEHFPGP) is the fragment of ACTH(4-10) analogue with prolonged neurotropic activity. The aim of the present work was to study the Semax effects on learning capability and pain sensitivity in white rats following intraperitoneal and intranasal administration in
G A Romanova et al.
Patologicheskaia fiziologiia i eksperimental'naia terapiia, (3)(3), 62-67 (2012-10-18)
It was stated, that with bilateral photochemically induced thrombosis of the prefrontal cortex peptide semax and the AB-Glu by intranasal injection provoke pronounced neuroprotective and antiamnestic action. Intranasal injection semax (250 mkg/kg/daily during six postoperative days) and AB-Glu (250 mkg/kg
Semax prevents functional impairments of avoidance response in rats.
A N Inozemtsev et al.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 448, 1-3 (2013-03-13)
K V Shevchenko et al.
Bioorganicheskaia khimiia, 37(4), 475-482 (2011-11-22)
Proteolysis of semax (Met-Glu-His-Phe-Pro-Gly-Pro, Sem) and its analogues ([Ala1]Sem, [Gly1]Sem, [Thr1]Sem, [Trp1]Sem) that are differ from semax in substitution of N-terminal Met residue were studied. It is shown that such replacement changes the rate of peptides degradation by N-aminopeptidases (EC
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