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生物来源
human
质量水平
重组
expressed in HEK 293 cells
检测方案
≥95% (SDS-GE)
形式
lyophilized powder
分子量
32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions)
35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)
技术
ligand binding assay: suitable
UniProt登记号
储存温度
−20°C
基因信息
human ... FASLG(356)
应用
ED50 = 1 ng/ml on A20 cells. Does not require any enhancer, as the modified linker sequence already facilitates the formation of active FasL complexes. rhsSuperFasL™ recognizes its receptor Fas (CD95) of the following species: human, rat, mouse.
生化/生理作用
Fas ligand has also been shown to be involved in the activation of non-apoptotic pathways including proliferation and NF-κ B activation.
Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).
法律信息
SuperFas Ligand is a trademark of Alexis Biochemicals Corp.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Harald Wajant et al.
Cytokine & growth factor reviews, 14(1), 53-66 (2002-12-18)
Fas (Apo-1, CD95) and Fas-Ligand (FasL, CD95L) are typical members of the TNF receptor and TNF ligand family, respectively, with a pivotal role in the regulation of apoptotic processes, including activation-induced cell death, T-cell-induced cytotoxicity, immune privilege and tumor surveillance.
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